盐酸氨溴索支气管镜下肺泡灌洗治疗重症肺炎支原体肺炎患儿的效果

Effects of bronchoalveolar lavage with Ambroxol hydrochloride in treatment of children with severe mycoplasma pneumoniae pneumonia

目的:观察盐酸氨溴索支气管镜下肺泡灌洗治疗重症肺炎支原体肺炎(SMPP)患儿的效果。方法:选取2022年12月至2023年12月该院收治的120例SMPP患儿进行前瞻性研究,按随机数字表法将其分为对照组和观察组各60例。对照组采用支气管镜下肺泡灌洗治疗,观察组采用盐酸氨溴索支气管镜下肺泡灌洗治疗,比较两组临床疗效、治疗前后炎性指标[降钙素原(PCT)、白细胞计数(WBC)、超敏C反应蛋白(hs-CRP)、白细胞介素-6(IL-6)]水平、临床症状持续时间、住院时间、血清学指标[乳酸脱氢酶(LDH)]水平和不良反应发生率。结果:观察组治疗总有效率为96.67%(58/60),高于对照组的86.67%(52/60),差异有统计学意义(P<0.05);治疗后,观察组PCT、WBC、hs-CRP、IL-6水平均低于对照组,差异有统计学意义(P<0.05);观察组发热、咳嗽、肺部啰音、胸部阴影等症状持续时间和住院时间均短于对照组,差异有统计学意义(P<0.05);治疗后,观察组LDH水平低于对照组,差异有统计学意义(P<0.05);两组不良反应发生率比较,差异无统计学意义(P>0.05)。结论:盐酸氨溴索支气管镜下肺泡灌洗治疗SMPP患儿可提高治疗总有效率,缩短症状持续时间和住院时间,降低炎性指标水平和LDH水平,效果优于单纯支气管镜下肺泡灌洗治疗。

Objective:To observe effects of bronchoalveolar lavage with Ambroxol hydrochloride in treatment of children with severe mycoplasma pneumoniae pneumonia(SMPP).Methods:A prospective study was conducted on 120 children with SMPP admitted to this hospital from December 2022 to December 2023.According to the random number table method,they were divided into control group and observation group,60 cases in each group.The control group was treated with bronchoalveolar lavage,while the observation group was treated with bronchoalveolar lavage with Ambroxol hydrochloride.The clinical efficacy,the inflammatory factor[procalcitonin(PCT),white blood cell count(WBC),high-sensitivity C-reactive protein(hs-CRP),interleukin-6(IL-6)]before and after the treatment,the duration of clinical symptoms,the hospitalization time,the serological index[lactate dehydrogenase(LDH)]level,and the incidence of adverse reactions were compared between the two groups.Results:The total effective rate of the observation group was 96.67%(58/60),which was higher than 86.67%(52/60)of the control group,and the difference was statistically significant(P<0.05).After the treatment,the levels of PCT,WBC,hs-CRP and IL-6 in the observation group were lower than those in the control group,and the differences were statistically significant(P<0.05).The duration of symptoms such as fever,cough,lung rale,chest shadow and the hospitalization time in the observation group were shorter than those in the control group,and the differences were statistically significant(P<0.05).After the treatment,the LDH level in the observation group was lower than that in the control group,and the difference was statistically significant(P<0.05).However,there was no significant difference in the incidence of adverse reactions between the two groups(P>0.05).Conclusions:Bronchoalveolar lavage with Ambroxol hydrochloride in the treatment of the children with SMPP can improve the total effective rate of treatment,shorten the duration of symptoms and the hospitalization time,and reduce the levels of inflammatory factors and LDH.Moreover,it is superior to single bronchoalveolar lavage treatment.