黄芪建中汤加减联合四联疗法治疗Hp阳性慢性胃炎患者的效果

Effects of Huangqi Jianzhong decoction (addition and subtraction) combined with quadruple therapy in the treatment of Hp-positive chronic gastritis

目的:观察黄芪建中汤加减联合四联疗法治疗幽门螺杆菌(Hp)阳性慢性胃炎患者的效果。方法:选取2021年9月至2022年9月该院收治的100例Hp阳性慢性胃炎患者进行前瞻性研究,按随机数字表法将其分为对照组与观察组各50例。对照组采取四联疗法治疗,观察组在对照组基础上联合黄芪建中汤加减治疗。比较两组临床症状缓解时间,治疗前后胃肠激素指标[胃动素(MOT)、胃蛋白酶原I(PGⅠ)、胃泌素(GS)]水平、中医证候积分,以及不良反应发生率。结果:观察组上腹胀痛、反酸、恶心、食欲不振缓解时间均短于对照组,差异有统计学意义(P<0.05);治疗后,两组MOT水平均高于治疗前,且观察组高于对照组,两组PGⅠ、GS水平均低于治疗前,且观察组低于对照组,差异有统计学意义(P<0.05);治疗后,两组腹部痞满、泛恶欲吐、嗳气返酸、隐痛呃逆、饥不欲食、泛吐清水等中医证候积分均低于治疗前,且观察组低于对照组,差异有统计学意义(P<0.05);两组不良反应发生率比较,差异无统计学意义(P>0.05)。结论:黄芪建中汤加减联合四联疗法治疗Hp阳性慢性胃炎患者可缩短临床症状缓解时间,改善胃肠激素指标水平,降低中医证候积分,其效果优于单纯四联疗法治疗。

Objective:To observe effects of Huangqi Jianzhong decoction(addition and subtraction)combined with quadruple therapy in treatment of patients with Helicobacter pylori(Hp)-positive chronic gastritis.Methods:A prospective study was conducted on 100 patients with Hp-positive chronic gastritis admitted to the hospital from September 2021 to September 2022.According to the random number table method,they were divided into control group and observation group,50 cases in each group.The control group was treated with quadruple therapy,while the observation group was treated with Huangqi Jianzhong decoction(addition and subtraction)on the basis of that of the control group.The remission time of clinical symptoms,the levels of gastrointestinal hormone indexes[motilin(MOT),pepsinogen I(PGI),gastrin(GS)]and the TCM syndrome score before and after the treatment,and the incidence of adverse reactions were compared between the two groups.Results:The relief time of abdominal distension,acid reflux,nausea and loss of appetite in the observation group was shorter than that in the control group,and the difference was statistically significant(P<0.05).After the treatment,the MOT levels of the two groups were higher than those before the treatment,and that in the observation group was higher than that in the control group;the levels of PGI and GS in the two groups were lower than those before the treatment,and those in the observation group were lower than those in the control group;and the differences were statistically significant(P<0.05).After the treatment,the scores of TCM syndromes such as abdominal fullness,nausea and vomiting,belching and acid reflux,dull pain and hiccups,hunger without desire for food,vomiting of water in the two groups were lower than those before the treatment,those in the observation group were lower than those in the control group,and the differences were statistically significant(P<0.05).However,there was no significant difference in the incidence of adverse reactions between the two groups(P>0.05).Conclusions:Huangqi Jianzhong decoction(addition and subtraction)combined with quadruple therapy can shorten the remission time of clinical symptoms,improve the levels of gastrointestinal hormones,and reduce the of TCM syndrome scores in the patients with Hp-positive chronic gastritis.Moreover,it is superior to single quadruple therapy.