胃疡宁丸联合瑞巴派特治疗活动期胃溃疡患者的效果

Effects of Weiyangning pills combined with Rebamipide in treatment of patients with active gastric ulcer

目的:观察胃疡宁丸联合瑞巴派特治疗活动期胃溃疡患者的效果。方法:选取2018—2022年该院收治的80例活动期胃溃疡患者进行前瞻性研究,按照随机数字表法将其分为对照组和观察组各40例。对照组采用瑞巴派特治疗,观察组在对照组基础上联合胃疡宁丸治疗,比较两组临床疗效,治疗前后中医证候积分、炎性因子[C反应蛋白(CRP)、白细胞介素-8(IL-8)、降钙素原(PCT)]水平、胃肠激素[胃泌素(GAS)、生长抑素(SS)]水平,以及不良反应发生率。结果:观察组治疗总有效率为95.00%(38/40),高于对照组的75.00%(30/40),差异有统计学意义(P<0.05);治疗后,两组胃脘疼痛、嗳气、食欲不振、反酸等中医证候积分均低于治疗前,且观察组低于对照组,差异有统计学意义(P<0.05);治疗后,两组CRP、IL-8、PCT水平均低于治疗前,且观察组低于对照组,差异有统计学意义(P<0.05);治疗后,两组GAS、SS水平均低于治疗前,且观察组低于对照组,差异有统计学意义(P<0.05);两组不良反应发生率比较,差异无统计学意义(P>0.05)。结论:胃疡宁丸联合瑞巴派特治疗活动期胃溃疡患者,可提高临床疗效,降低中医证候积分,减轻机体炎症反应,改善胃肠激素水平,效果优于单纯瑞巴派特治疗。

Objective:To observe effects of Weiyangning pills combined with Rebamipide in treatment of patients with active gastric ulcer.Methods:A prospective study was conducted on 80 patients with active gastric ulcer admitted to the hospital from 2018 to 2022.According to the random number table method,they were divided into control group and observation group,40 cases in each group.The control group was treated with Rebamipide,while the observation group was treated with Weiyangning pills on the basis of that of the control group.The clinical efficacy,the TCM syndrome scores,the inflammatory factors[C-reactive protein(CRP),interleukin-8(IL-8),procalcitonin(PCT)]levels,the gastrointestinal hormones[gastrin(GAS),somatostatin(SS)]levels,and the incidence of adverse reactions were compared between the two groups before and after the treatment.Results:The total effective rate of the observation group was 95.00%(38/40),which was higher than 75.00%(30/40)of the control group,and the difference was statistically significant(P<0.05).After treatment,the scores of TCM syndromes such as epigastric pain,belching,loss of appetite and acid reflux in the two groups were lower than those before the treatment,those in the observation group were lower than those in the control group,and the differences were statistically significant(P<0.05).After treatment,the levels of CRP,IL-8 and PCT in the two groups were lower than those before the treatment,those in the observation group were lower than those in the control group,and the differences were statistically significant(P<0.05).After treatment,the levels of GAS and SS in the two groups were lower than those before the treatment,those in the observation group were lower than those in the control group,and the differences were statistically significant(P<0.05).However,there was no significant difference in the incidence of adverse reactions between the two groups(P>0.05).Conclusions:Weiyangning pills combined with Rebamipide in the treatment of the patients with active gastric ulcer can improve the clinical efficacy,reduce the TCM syndrome scores,reduce the body’s inflammatory response,and improve the levels of gastrointestinal hormones.Moreover,it is superior to single Rebamipide treatment.