甘油三酯葡萄糖指数与急性胰腺炎严重程度的相关性分析

Correlation Analysis Between Triglyceride-Glucose Index and the Severity of Acute Pancreatitis

目的:探讨甘油三酯葡萄糖(triglyceride glucose, TyG)指数与急性胰腺炎(acute pancreatitis, AP)严重程度的相关性。方法:选取2021年1月至2023年8月于湖北医药学院附属随州医院住院的534例AP患者,根据严重程度分为重症急性胰腺炎(SAP)组99例和非重症急性胰腺炎(NSAP)组435例,比较两组间一般临床资料、实验室指标的差异。用二元Logistic回归探讨AP严重程度的独立危险因素,并绘制相应的受试者工作特征(ROC)曲线,评估其预测SAP的准确性和可靠性。探讨TyG指数在不同病因里对SAP的预测价值。结果:SAP的独立危险因素为年龄、凝血酶原时间(PT)、TyG指数,男性是SAP的独立保护因素。年龄、PT、TyG指数及三者联合指标对SAP的诊断都具有一定价值,其曲线下面积依次为0.601[95%CI(0.537,0.665),P=0.002]、0.62[95%CI(0.559,0.681),P<0.001]、0.747[95%CI(0.699,0.795),P<0.001]、0.829[95%CI(0.782, 0.876),P<0.001]。TyG指数在胆源性、高脂血症性及其他病因性急性胰腺炎组中预测SAP的AUC分别为0.890[95%CI(0.821,0.959),P<0.001]、0.766[95%CI(0.626,0.906),P<0.001]、0.802[95%CI(0.737,0.867),P<0.001]。结论:TyG指数与AP严重程度呈正相关,年龄、PT、TyG指数联合可以提高预测AP严重程度的准确性。TyG指数在胆源性、高脂血症性及其他病因性急性胰腺炎组中对SAP均有预测价值,但存在差异。

Objective To analyze the correlation between triglyceride-glucose(TyG)index and the severity of acute pan⁃creatitis(AP).Methods A total of 534 AP patients admitted to Suizhou central hospital,Hubei University of Medicine from January 2021 to August 2023 were selected.They were divided into a severe acute pancreatitis(SAP,99 cases)group,and a non-severe acute pancreatitis(NSAP,435 cases)group according to the severity.General clinical data and laboratory indices were compared between the two groups.Independent risk factors for the severity of AP were identified u⁃sing binary logistic regression,and the predictive accuracy and reliability for SAP were assessed with receiver operating characteristic(ROC)curve.The predictive value of the TyG index for SAP was explored across different etiologies.Re⁃sults Independent risk factors for SAP included age,prothrombin time(PT),and TyG index,and male was a protective factor against SAP.Age,PT,and TyG index each and their combination had diagnostic value for SAP,with their respective areas under the curve(AUC)of 0.601[95%CI(0.537,0.665),P=0.002],0.62[95%CI(0.559,0.681),P<0.001],0.747[95%CI(0.699,0.795),P<0.001],and 0829[95%CI(0.782,0.876),P<0.001].The AUC of the TyG index for predicting SAP in biliary,hyperlipidemic,and other etiologies of AP was 0.890[95%CI(0.821,0.959),P<0.001],0.766[95%CI(0.626,0.906),P<0.001],and 0.802[95%CI(0.737,0.867),P<0.001],respectively.Conclusion The TyG index is positively correlated with the severity of AP,and the combination of age,PT,and TyG index can improve the accuracy of predicting the severity of AP.The TyG index demonstrates predictive value for SAP across dif⁃ferent etiologic groups of AP,but with variations.