摘要
缺血性脑卒中(ischemic stroke)是全球人口死亡和残疾的主要原因,其发病过程复杂且治疗方法十分有限。近年来,纳米药物递送系统(nano-drug delivery systems,NDDS)在治疗脑部疾病方面显示出巨大的潜力。纳米载体可以携带药物通过血脑屏障,并通过靶向配体的修饰将药物递送到特定的细胞。本文主要综述了缺血性脑卒中的发病机制以及当前治疗方法的局限性,重点介绍了纳米药物递送系统治疗缺血性脑卒中的进展。最后提出该领域的挑战和未来方向,以推动纳米药物递送系统在缺血性脑卒中治疗中的发展。
Ischemic stroke is a leading cause of death and disability worldwide,with a complex pathogenesis and limited therapeutic options.In recent years,nano-drug delivery systems(NDDS)have shown great potential in the treatment of brain diseases.Nanocarriers can transport drugs across the blood-brain barrier and target diseased cells through the modification of targeting ligands.This article reviews the pathogenesis of ischemic stroke and the limitations of current therapeutic approaches,focusing on the progress of nano-drug delivery systems in the treatment of ischemic stroke.The challenges and future directions in this field are proposed,aiming to advance the development of nanomedicine delivery systems for the treatment of ischemic stroke.
作者
张谦
王斯柔
黄志华
ZHANG Qian;WANG Si-Rou;HUANG Zhi-Hua(School of Basic Medical Sciences,Gannan Medical University,Gannan Medical University,Ganzhou 341000,China;Key Laboratory of Ministry of Education for Prevention and Treatment of Cardiovascular and Cerebrovascular Diseases,Gannan Medical University,Ganzhou 341000,China)
出处
《生理科学进展》
CAS
北大核心
2024年第3期199-206,共8页
Progress in Physiological Sciences
基金
国家自然科学基金项目(31960190)
心脑血管疾病防治教育部重点实验室开放课题(XN201811)
江西省自然科学基金项目(20192BAB205117)资助课题。
