Rheb1在糖尿病及其并发症中作用的研究进展

Research progress on the role of Rheb1 in diabetes mellitus and its complications

DM是以IR和胰岛β细胞损伤导致血糖持续升高为特征的慢性代谢性疾病。Rheb1调控细胞生长和代谢,通过哺乳动物雷帕霉素复合体1靶蛋白通路促进胰岛β细胞生长、增殖及Ins分泌,影响血管内皮细胞、巨噬细胞和肾小球足细胞功能,参与动脉粥样硬化及DKD的发生发展。本文综述Rheb1在DM及其并发症中作用的研究进展。

Diabetes mellitus(DM) is a chronic metabolic disease characterized by sustained elevation of blood glucosedue toin sulin resistance and islet β cell damage.Rheb1 regulates cell growth and metabolism,promotes islet β cell growth,proliferation and insulin secretion through the mTORC1 pathway,affects the function of vascular endothelial cells,macrophages and glomerular podocytes,and participates in the occurrence and development of atherosclerosis and diabetic kidney disease.This article reviews the research progress on the role of Rheb1 in DM and its complications.