乳腺癌患者血清甲状腺激素与肿瘤标志物之间的关系及对肿瘤转移的预测价值

Relationship between Serum Thyroid Hormones and Tumor Markers in Breast Cancer Patients and the Predictive Value of Tumor Metastasis

目的探讨乳腺癌患者血清甲状腺激素与肿瘤标志物之间的关系及对肿瘤转移的预测价值。方法选取我院2019年4月至2022年6月进行乳腺癌根治术的157例(均完成6个月随访)患者为研究对象,根据术后6个月是否发生转移分为转移组(43例)和未转移组(114例)。比较两组术后血清甲状腺激素[抗甲状腺过氧化物酶抗体(TPOAb)、甲状腺球蛋白抗体(TGAb)、促甲状腺激素受体抗体(TRAb)]与肿瘤标志物[癌胚抗原(CEA)、糖类抗原15-3(CA153)、糖类抗原125(CA125)]水平,分析血清甲状腺激素水平与肿瘤标志物及术后转移的相关性,偏回归分析乳腺癌患者术后转移的影响因素,根据受试者工作特征(ROC)分析血清TPOAb、TGAb、TRAb水平联合检测对乳腺癌患者术后转移的预测价值。结果与未转移组相比,转移组术后血清TPOAb、TGAb、TRAb、CEA、CA153、CA125水平均较高(P<0.05);相关性结果显示,术后血清TPOAb、TGAb、TRAb水平均与术后血清CEA、CA153、CA125水平、术后转移呈正相关(P<0.05);Logistic回归分析显示,术后血清TPOAb(>67.69IU/m L)、TGAb(>28.80IU/m L)、TRAb(>3.88IU/L)水平是乳腺癌患者术后发生转移的危险因素(P<0.05);术后血清TPOAb、TGAb、TRAb水平联合预测乳腺癌患者术后转移的价值良好。结论乳腺癌患者术后血清TPOAb、TGAb、TRAb水平与CEA、CA153、CA125水平紧密相关,联合检测能有效提高乳腺癌患者术后转移的诊断敏感度、特异度,为临床干预提供数据参考。

Objective To investigate the relationship between serum thyroid hormones and tumor markers in breast cancer patients and the predictive value of tumor metastasis.MethodsOne hundred and fifty-seven patients(all completed 6-month follow-up)who underwent radical breast cancer surgery from April 2019 to June 2022 in our hospital were selected for the study,and were divided into metastatic group(43 cases)and non-metastatic group(114 cases)according to whether metastasis occurred at 6 months after surgery.The levels of serum thyroid hormones[thyroid peroxidase antibody(TPOAb),thyroglobulin antibody(TGAb),thyroid receptor promoting antibody(TRAb)]and tumor markers[carcinoembryonic antigen(CEA),glycoantigen 15-3(CA153),glycoantigen 125(CA125)]were compared between the two groups after surgery,and the levels of serum thyroid hormones were analyzed in relation to tumor markers and correlation of postoperative metastasis,partial regression analysis of factors influencing postoperative metastasis in breast cancer patients,and analysis of the predictive value of combined serum TPOAb,TGAb,TRAb levels on postoperative metastasis in breast cancer patients according to subject work characteristics(ROC).Results Compared with the non-metastatic group,postoperative serum TPOAb,TGAb,TRAb,CEA,CA153,CA125 levels were higher in the metastatic group(P<0.05);correlation results showed that postoperative serum TPOAb,TGAb,TRAb levels were positively correlated with postoperative serum CEA,CA153,CA125 levels,and postoperative metastasis(P<0.05)Logistic regression analysis showed that postoperative serum TPOAb(>67.69 IU/mL),TGAb(>28.80 IU/mL),and TRAb(>3.88 IU/L)levels were risk factors for postoperative metastasis in breast cancer patients(P<0.05);the combination of postoperative serum TPOAb,TGAb,and TRAb levels was a good predictor of postoperative metastasis in breast cancer patients.The value of the combination of postoperative serum TPOAb,TGAb and TRAb levels to predict postoperative metastasis in patients was good.ConclusionThe postoperative serum TPOAb,TGAb and TRAb levels of breast cancer patients are closely correlated with CEA,CA153 and CA125 levels,and the combined test can effectively improve the diagnostic sensitivity and specificity of postoperative metastasis in breast cancer patients and provide data reference for clinical intervention.