培元健脾针药方治疗2型糖尿病合并肥胖症临床疗效观察

Clinical Observation on Therapeutic Efficacy of Peiyuanjianpi Acupuncture and Medicine Prescription on Type 2 Diabetes Mellitus Complicated with Obesity

目的:旨在通过观察针药结合“固本培元,健脾和胃”法治疗肥胖型2型糖尿病患者的临床疗效。方法:选用2019年3月至2022年3月80例肥胖型2型糖尿病患者,依照随机数字表法分为两组,每组40例。对照组予盐酸二甲双胍片结合米格列醇片。医治组在对照组基础上,加用针药联合疗法。两组均医治30d(1个疗程)。比较两组治疗前后相关观察指标的差异。结果:医治组总有效率高于对照组(P<0.05)。两组治疗后体重指数(Body Mass Index,BMI)、总胆固醇(Total cholesterol,TC)、甘油三脂(Triglyceride,TG)、低密度脂蛋白(Low-density lipoprotein cholesterol,LDL-C)、空腹血糖(Fasting plasma glucose,FPG)、血清空腹胰岛素(Fasting insulin serum,FINS)、胰岛素指数(HOMA-Insulin Resistance,HOMA-IR)与医治组比较有显著性差异(P<0.05),且治疗组均优于对照组(P<0.05)。在降低腰臀比(Waist-to-hip ratio,WHR)、胰岛素敏感性指数(Insulin action index,IAI)方面差异无统计学意义(P>0.05),阐明医治组和对照组在降低WHR、IAI方面无显著差异。结论:针药结合“固本培元,健脾和胃”法治疗肥胖型2型糖尿病临床疗效确切,轻身、减脂、恢复血糖水平,治疗胰岛素抵抗状态成效卓著,尤其对提高FINS、高密度脂蛋白(High-density lipoprotein cholesterol,HDL-C)、降低TC、LDL-C方面成效突出。对降低BMI、FPG、TG、HOMA-IR作用值得肯定,无副作用,值得临床推行运用。

Objective:To observe the clinical effect of acupuncture and medicine combined with"Gubenpeiyuan,jianpihewei"in the treatment of obese type 2 diabetes.Methods:80 obese patients with type 2 diabetes mellitus from March 2019 to March 2022 were selected and divided into 2 groups with 40 patients in each group according to the random number table method.The control group was given metformin hydrochloride tablets combined with miglitol tablets.Based on the control group,the treatment group was added with needle and drug combination therapy.Both groups were treated for 30 days(1 course).The differences of relevant observation indexes before and after treatment were compared between the two groups.Results:The total effective rate of the treatment group was higher than that of the control group(P<0.05).There were significant differences in BMI,FPG,FINS,HOMA-IR,TC,TG,and LDL-C between the two groups after treatment compared with before treatment(P<0.05),and the treatment group was superior to the control group(P<0.05).There was no obvious statistical difference in reducing WHR and IAI(P>0.05),indicating that there was no remarkable difference in the reduction of WHR and IAI between the treatment group and the control group.Conclusion:Acupuncture and medicine combined with"Gubenpeiyuan,jianpihewei"has definite clinical efficacy in the treatment of obesity-type 2 diabetes mellitus.It is effective in reducing body weight,reducing fat,restoring blood glucose level,and treating insulin resistance,especially in improving FINS,HDL-C,and reducing TC and LDL-C.The effect of reducing BMI,FPG,TG and HOMA-IR is worthy of affirmation,without side effects,and worthy of clinical application.