群体感应介导的乳酸菌益生作用研究进展

Advances in Quorum Sensing-mediated Probiotic Effects of Lactic Acid Bacteria

近年来,乳酸菌的益生特性及机制得到了广泛研究,但大多数研究集中于单菌的内在调控机制上。群体感应(Quorum sensing,QS)作为一种基于信号分子的细菌通信机制,在乳酸菌生长代谢和抵抗环境应激的过程中具有重要作用。本文介绍了乳酸菌中的3种QS类型及其作用机制,综述了QS调控乳酸菌生物膜形成、细菌素产生、耐酸特性等生理功能的作用机制,并阐述了QS介导乳酸菌益生特性和对致病菌拮抗作用的调控机制,为乳酸菌益生功能的研究与应用提供了理论指导。

Recent years,the probiotic properties and mechanisms of lactic acid bacteria have been widely studied,most of them focused on the intrinsic regulatory mechanisms of single colony.Quorum sensing(QS),as a signaling molecule-based bacterial communication mechanism,which play an important role in the growth and metabolism of lactic acid bacteria and resistance to environmental stress.This paper introduces three types of QS in lactic acid bacteria and their mechanisms of action,summarizes the mechanisms of QS in regulating the physiological functions of lactic acid bacteria,such as biofilm formation,bacteriocin production,and acid resistance,and describes the mechanisms of QS-mediated regulation of the probiotic properties of lactic acid bacteria and antagonism against pathogenic bacteria to provide theoretical guidance for the research and application of the probiotic functions of lactic acid bacteria.