复合益生菌联合氯雷他定、糠酸莫米松鼻喷雾剂对过敏性鼻炎患儿的治疗效果及其作用机制分析

Therapeutic effect and mechanism of compound probiotics combined with loratadine and Mometasone furoate nasal spray in children with allergic rhinitis

目的:探讨复合益生菌联合氯雷他定、糠酸莫米松鼻喷雾剂对过敏性鼻炎患儿的治疗效果,并分析其作用机制。方法:选择96例过敏性鼻炎患儿为研究对象,按照不同治疗方案分为对照组和观察组,每组各48例。对照组行氯雷他定联合糠酸莫米松鼻喷雾剂治疗;观察组行双歧杆菌乳杆菌三联活菌片联合氯雷他定、糠酸莫米松鼻喷雾剂治疗。治疗8周后,比较两组患者治疗效果、肠道菌群、免疫功能及不良反应发生情况。结果:治疗8周后,两组鼻塞、鼻痒、喷嚏及流涕评分均降低,且观察组低于对照组(P<0.05);血清γ干扰素(IFN-γ)、白细胞介素4(IL-4)水平均升高,且观察组高于对照组(P<0.05);粪便双歧杆菌及乳酸杆菌含量均升高,且观察组高于对照组(P<0.05);大肠杆菌含量均降低,且观察组低于对照组(P<0.05)。观察组治疗有效率高于对照组(P<0.05);且不良反应发生率低于对照组(P<0.05)。结论:在氯雷他定、糠酸莫米松鼻喷雾剂的基础上联合复合益生菌有利于提升过敏性鼻炎患儿的治疗效果,降低不良反应发生风险,其作用机制与改善肠道菌群、免疫调节功能相关。

Objective:To investigate the therapeutic effect of compound probiotics combined with loratadine and Mometasone furoate nasal spray on children with allergic rhinitis and analyze its mechanism.Methods:96 children with allergic rhinitis were divided into control group and observation group according to different treatment methods,with 48 cases in each group.The control group was treated with loratadine combined with mometasone furoate nasal spray,and the observation group was treated with bifidobacterium lactobacillus triple viable tablets combined with loratadine combined with mometasone furoate nasal spray.After 8 weeks of treatment,the therapeutic effect,intestinal flora,immune function and occurrence of adverse reactions were compared between the two groups.Results:After 8 weeks of treatment,the scores of nasal congestion,nasal itching,sneezing and runny nose in both groups decreased,and the observation group was lower than the control group(P<0.05),serum interferonγ(IFN-γ)and interleukin-4(IL-4)in both groups increased,and the observation group was higher than the control group(P<0.05).The contents of fecal bifidobacterium and lactobacillus increased,and the observation group was higher than the control group(P<0.05).The contents of Escherichia coli decreased,and and the observation group was lower than the control group(P<0.05).The clinical effective rate of the observation group was higher than that of the control group(P<0.05),and the incidence of adverse reactions was linferior to the control group(P<0.05).Conclusion:Combined with compound probiotics on the basis of loratadine and Mometasone furoate nasal spray can improve the therapeutic effect of allergic rhinitis in children and reduce the risk of adverse reactions.The mechanism of action is related to improving intestinal flora and regulating immune function.