6-异丙基-3,4-二氢嘧啶类化合物的高效催化合成

High efficiency catalytic synthesis of the 6-isopropyl-3,4-dihydropyrimidones

开发了一种新型、简便的合成方法,在无溶剂条件下,以4,5-甲基-L-脯氨酸为催化剂,催化比吉内利反应(Biginelli reaction)高效合成6-异丙基-3,4-二氢嘧啶类化合物。反应条件温和,催化剂环保,产率优异(高达99%),可以获得广泛的具有显著生物活性的目标产物。

A novel and simple catalytic methodology to highly efficient synthesis of the 6-isopropyl-3,4-dihydropyrimidines via Biginelli condensation using efficient,eco-friendly 4,5-methano-L-prolines as catalyst under solvent-free condition has been developed.A variety of compounds with excellent biological activity was obtained in good to excellent high yields(up to 99%)under mild conditions.