摘要
开发了一种新型、简便的合成方法,在无溶剂条件下,以4,5-甲基-L-脯氨酸为催化剂,催化比吉内利反应(Biginelli reaction)高效合成6-异丙基-3,4-二氢嘧啶类化合物。反应条件温和,催化剂环保,产率优异(高达99%),可以获得广泛的具有显著生物活性的目标产物。
A novel and simple catalytic methodology to highly efficient synthesis of the 6-isopropyl-3,4-dihydropyrimidines via Biginelli condensation using efficient,eco-friendly 4,5-methano-L-prolines as catalyst under solvent-free condition has been developed.A variety of compounds with excellent biological activity was obtained in good to excellent high yields(up to 99%)under mild conditions.
作者
陈晓霞
黄清俊
吴卓
CHEN Xiaoxia;HUANG Qingjun;WU Zhuo(School of Ecological Technology and Engineering,Shanghai Institute of Technology,Shanghai 201418,China;Shanghai Engineering Research Center of Green Fluoropharmaceutical Technology,Shanghai 201418,China)
出处
《应用技术学报》
2024年第2期190-196,共7页
Journal of Technology