国内首例淋巴浆细胞性斑块

The first case of Lymphoplasmacytic plaque in China

报告国内首例淋巴浆细胞性斑块。患儿男,9岁。右前臂伸侧红色斑块7年。皮肤科检查:右前臂伸侧不规则红色斑块,上覆白色鳞屑。皮损组织病理:连续性角化不全,表皮不规则增生,局部颗粒层变薄,基底层液化变性,真皮浅中层较密集的淋巴细胞、浆细胞及组织细胞浸润。免疫组化:真皮层浅中层浆细胞膜CD38及CD138弥漫散在阳性。诊断:淋巴浆细胞性斑块。给予克立硼罗软膏外涂治疗,2个月后可见红斑较前变平。

To report the first case of lymphoplasmacytic plaque in China.A 9-year-old boy presented with a red plaque on the extension of the right forearm for 7 years.Dermatological examination revealed irregular red plaques overlying white scales on the extension of the right forearm.Histopathology of the skin lesions showed continuous parakeratosis,irregular epidermal hyperplasia,thinning of the local granular layer,liquefaction degeneration of the basal layer,and dense infiltration of lymphocytes,plasma cells and histiocytes in the superficial and middle dermis.Immunohistochemical study showed that CD38 and CD138 were diffusely positive in plasma cell membrane in the superficial and middle dermis.The diagnosis was lymphoplasmacytic plaque.After external application of Crisaborole Ointment,the erythema flattened two months later.