孔板模具结构对挤出造粒形貌的影响研究

Study on the influence of orifice mold structure on extrusion granulation morphology

为深入研究挤压造粒过程中孔板模具对造粒药粒形貌和质量的影响,运用有限元方法,采用数值模拟对挤压造粒过程药料的受压情况、孔板压力分布情况进行分析,通过仿真模拟手段对孔板模具的孔数、孔径、孔板厚度进行初步模拟设计,按照孔板模具设计原则进行多方案模具设计,通过代料试验,研究了不同孔数、孔径、孔分布、模具材质等因素对造粒效果、药粒尺寸、造粒得率、药粒烘干、药料塑化成型过程的影响。结果表明:当孔板模具设计为孔径10 mm/162孔、孔排列成正六边形、材质为铜质、孔设计为小进大出的结构时,药粒受压分布均匀,造粒所得药粒塑化适当、尺寸均一,获得挤压造粒最佳药粒形貌和质量,保证后续塑化过程中药粒能够快速地溶解于溶剂中,最终实现快速、均质、安全塑化过程,为后工艺实现连续化生产、达到最佳产品质量提供可靠支撑。

In order to further study the influence of orifice die on the morphology and quality of particles in the process of extrusion pelletizing,finite element method and numerical simulation were used in this paper to analyze the pressure situation of charge and the pressure distribution of orifice plate in the process of extrusion pelletizing.The number of holes,aperture and thickness of orifice plate in the orifice die were simulated by means of simulation.According to the design principle of orifice mold design of multi-scheme design,through the experimental study of different hole number,aperture,hole distribution,mold material and other factors,on the effect of granulation effect,granule size,granulation yield,granule drying,plastic molding process.The results showed that when the hole plate mold was designed with a diameter of 10 mm/162 holes,the holes were arranged into a regular hexagon,the material was copper,and the holes were designed with a structure of small inlet and large outlet,the particles were distributed evenly under pressure,and the particles obtained from granulation were plasticized appropriately and uniform in size,so as to obtain the best morphology and quality of the particles in extrusion granulation,and ensure that the particles could be quickly dissolved in the solvent in the subsequent plasticizing process.Finally,rapid,homogeneous and safe plasticizing process is realized,providing reliable support for continuous production and optimal product quality.