老年男性2型糖尿病患者血清睾酮与体重指数的相关性研究

Study of the association between serum totaltestosterone and body mass index in elderly male patients with type 2 diabetes mellitus

目的研究老年男性2型糖尿病(T2DM)患者血清总睾酮(TT)与体重指数(BMI)的相关性。方法选取老年男性T2DM患者123例,测量其身高、体重并计算BMI,检测血清TT、糖脂代谢等指标。依据BMI将研究对象分为正常体重组(18.0≤BMI<24.0 kg/m^(2))、超重组(24.0≤BMI<28.0 kg/m^(2))和肥胖组(BMI≥28.0 kg/m^(2))。比较、分析各组临床指标。结果随着BMI上升,正常体重、超重、肥胖组TT依次下降(P<0.05)。Pearson相关分析结果表明,TT与BMI呈负相关(P<0.05)。多重线性回归分析显示:BMI、年龄、低密度脂蛋白胆固醇(LDL-C)、空腹血糖(FPG)、估算的肾小球滤过率(eGFR)是TT的影响因素。结论老年男性T2DM患者血清TT水平与BMI呈负相关,超重、肥胖是血清TT下降的影响因素。

Objective To investigate the association between serum total testosterone(TT)and body mass index(BMI)in elderly male patients with type 2 diabetes mellitus(T2DM).Methods A total of 123 elderly male T2DM patients were selected to measure their height,weight and calculate the BMI,and detect serum TT,glucose and lipid metabolism indexes and so on.According to BMI,the study objects were divided into normal weight group(18.0≤BMI<24.0 kg/m^(2)),overweight group(24.0≤BMI<28.0 kg/m^(2))and obese group(BMI≥28.0 kg/m^(2)).The clinical indexes of each group were compared and analyzed.Results With the increase of BMI,TT of normal weight,overweight and obese group decreased successively(P<0.05).Pearson correlation analysis showed that TT was negatively correlated with BMI.Multiple linear regression analysis showed that BMI,age,LDL-C,FPG and eGFR were the influencing factors of TT.Conclusion Serum TT level was negatively correlated with BMI in elderly male patients with T2DM.Overweight and obesity are the influencing factors of serum TT decline.