H_(2)S-miRNA串扰在神经系统疾病中的研究现状

Research status of H_(2)S-miRNA crosstalk in neurological diseases

硫化氢(H_(2)S)是新型的内源性神经调节剂,在神经系统疾病中发挥着重要作用。微小RNAs(miRNAs)是神经系统疾病的关键调节因子,主要与靶基因mRNA的3′非翻译区靶向结合,抑制mRNA翻译并阻断其表达来发挥神经保护作用。H_(2)S和miRNA在帕金森病、脑卒中、脊髓疾病等神经系统疾病的发病过程中也起着重要作用。本文就H_(2)S和miRNA串扰对神经系统疾病的保护作用进行总结,探讨其对神经系统疾病的治疗作用。

Hydrogen sulfide(H_(2)S) is an emerging endogenous neuromodulator that holds significant potential in the realm of neurological diseases. Its role encompasses reducing neuronal damage, inhibiting excessive activation of striatal astrocytes, and regulating cerebrovascular function, among other physiopathological pathways. Conversely, microRNAs(miRNAs) are widely recognized as pivotal regulators of neurological diseases. They primarily target the 3′ untranslated region of the target gene mRNA, impeding mRNA translation and hindering its expression to impart neuroprotective effects. Recent findings have underscored the crucial involvement of H_(2)S and miRNAs in the pathogenesis of various neurological disorders such as Parkinson's disease, stroke, and spinal cord diseases, thereby garnering significant attention. This paper comprehensively summarizes the protective effects arising from the interplay between H_(2)S and miRNAs in neurological diseases, while also delving into the potential therapeutic efficacy they hold for such conditions.