银莱汤治疗小儿肺炎支原体肺炎的临床疗效及对血清Fbg、G-CSF水平的影响

Clinical efficacy of Yinlai decoction in treating mycoplasma pneumoniae pneumonia in children and its impacts on serum Fbg and G-CSF levels

目的:探究银莱汤治疗小儿肺炎支原体肺炎(MPP)的临床疗效及对血清纤维蛋白原(Fbg)、血清粒细胞集落刺激因子(G-CSF)水平的影响。方法:通过随机数字表法将选取的199例于2021年3月~2023年3月来我院进行MPP治疗的患儿分为观察组(99例)和对照组(100例),对照组患者采用阿奇霉素进行常规治疗,观察组在对照组常规治疗的基础上给予银莱汤,对两组患者的中医证候积分、临床疗效、肺功能指标和血清学指标做对比。结果:观察组和对照组患儿治疗后的中医证候积分水平均下降,且对照组患儿的积分下降水平不及观察组显著(P<0.05);临床总有效率在观察组和对照组中分别为91.92%和83.00%,经对比有统计学意义(P<0.05);两组患者治疗后的第一秒用力呼气末容积(FEV_(1))、用力肺活量(FVC)、呼气峰流速值(PEF)数值均有所增加,且对照组患者的各项肺功能指标数值增加情况均不及观察组明显(P<0.05);两组患者治疗后的白细胞介素-8(IL-8)、肿瘤坏死因子-α(TNF-α)、血清纤维蛋白原(Fbg)、血清粒细胞集落刺激因子(G-CSF)等血清学指标水平均有所降低,且对照组患儿的各项血清学指标降低水平均明显不及观察组(P<0.05)。结论:银莱汤能够有效提高MPP患儿的临床疗效,降低血清Fbg和G-CSF水平。

Objective:To explore the clinical efficacy of Yinlai decoction in treating mycoplasma pneumoniae pneumonia(MPP)in children and its impacts on serum fibrinogen(Fbg)and granulocyte colony stimulating factor(G-CSF)levels.Methods:From March 2021to March 2023,199selected children who underwent MPP treatment in our hospital were grouped into an observation group(99cases)and a control group(100cases)using a random number table method,the control group received routine treatment with azithromycin,the observation group was given Yinlai decoction based on routine treatment in the control group,the TCM syndrome scores,clinical efficacy,lung function indicators,and serum indicators of the two groups were compared.Results:Both the observation group and the control group showed a decrease in the level of traditional Chinese medicine syndrome scores after treatment,and the decrease in scores in the control group was not as obvious as that in the observation group(P<0.05);the total clinical effective rate in the observation group and control group was 91.92% and 83.00%,respectively,with statistical significance(P<0.05);the forced end expiratory volume in first second(FEV1),forced vital capacity(FVC),and peak expiratory flow rate(PEF)values of both groups increased after treatment,and the increases in various lung function indicators in the control group were not as obvious as those in the observation group(P<0.05);after treatment,the levels of serum indicators such as interleukin-8(IL-8),tumor necrosis factor-α(TNF-α),serum fibrinogen(Fbg),and granulocyte colony stimulating factor(G-CSF)in both groups decreased,and the decreases in various serum indicators in the control group were obviously lower than those in the observation group(P<0.05).Conclusion:Yinlai decoction can effectively improve the clinical efficacy of MPP patients and reduce serum Fbg and G-CSF levels.