透邪清心汤加减治疗病毒性心肌炎的疗效及对患者左心室整体收缩功能、血清ANF、炎症因子的影响

Effect of Tongxie Qingxin decoction on left ventricular global systolic function and serum ANF,inflammatory factors in patients with VMC

目的:分析透邪清心汤加减治疗急性病毒性心肌炎(VMC)的疗效对患者左心室整体收缩功能、血清心钠素(ANF)、白细胞介素-17(IL-17)、干扰素-γ(IFN-γ)、白细胞介素-35(IL-35)和白细胞介素-10(IL-10)的影响。方法:选取我院(2016年4月~2019年4月)收治的VMC患者94例,采用随机数字法分为对症组(常规对症)和联合组(常规对症+透邪清心汤加减)。记录2组治疗前后心功能指标、ANF、炎症因子的变化,并统计2组临床治疗总有效率和不良反应率。结果治疗后,联合组总有效率(91.49%)高于对症组(74.47%),差异具有统计学意义(P<0.05)。治疗后,2组每搏输出量(SV)、IL-10、IL-35、心排血量(CO)、ANF、左室射血分数(LVEF)水平较治疗前上升,IL-17、FIN-γ水平较治疗前下降,联合组心功能指标、IL-10、IL-35、ANF水平高于对症组,IL-17、FIN-γ水平低于对症组(P<0.05)。治疗期间,联合组总不良反应率(14.89%)与对症组(10.64%)比较,差异不具有统计学意义(P>0.05)。结论:透邪清心汤加减治疗VMC可调节血清ANF、IL-10、IL-17、IL-35、IFN-γ的表达水平,改善心功能,提高疗效,且不增加不良反应。

Objective To analyze the effects of Tongjie Qingxin Decoction on left ventricular systolic function,serum natriuretic hormone(ANF),interleukin-17(IL-17),interferon-γ(IFN-γ),interleukin-35(IL-35)and interleukin-10(IL-10)in patients with acute viral myocarditis(VMC).MethodsNinety-four VMC patients admitted to our hospital(April 2016to April 2019)were selected and divided into symptomatic group(conventional symptomatic)and combined group(conventional symptomatic+T&L Qingxin Decoction plus or minus)by random number method.The changes of cardiac function indexes,ANF and inflammatory factors before and after treatment were recorded in the 2groups,and the total effective rate and adverse reaction rate of the 2groups were statistically analyzed.ResultsAfter treatment,the total effective rate of combination group(91.49%)was higher than that of symptomatic group(74.47%),and the difference was statistically significant(P<0.05).After treatment,stroke output(SV),IL-10,IL-35,cardiac output(CO),ANF,left ventricular ejection fraction(LVEF)levels in 2groups were increased compared with before treatment,while IL-17and FIN-γlevels were decreased compared with before treatment.Cardiac function indexes,IL-10,IL-35and ANF levels in the combined group were higher than those in the symptomatic group.IL-17and FIN-γlevels were lower than those in symptomatic group(P<0.05).During treatment,there was no significant difference in the total adverse reaction rate between the combined group(14.89%)and the symptomatic group(10.64%)(P>0.05).ConclusionTreating VMC with TVC can regulate the expression levels of serum ANF,IL-10,IL-17,IL-35and IFN-γ,improve cardiac function and efficacy,and do not increase adverse reactions.