除风益损汤联合聚乙二醇滴眼液对白内障术后干眼症患者疗效及泪液炎症因子水平分析

Analysis of the therapeutic effect and tear inflammatory factor levels of Chufeng Yisun decoction combined with polyethylene glycol eye drops on patients with dry eye after cataract surgery

目的:分析除风益损汤联合聚乙二醇滴眼液对白内障术后干眼症的疗效。方法:选择2020年8月~2022年9月期间我院收治的100例白内障术后干眼症患者为研究对象,按简单随机数字表法将其分为对照组(50例,给予聚乙二醇滴眼液治疗)和联合组(50例,在对照组的基础上给予除风益损汤治疗)。观察比较两组临床疗效、泪膜稳定性指标、眼表疾病指数(OSDI)、最佳矫正视力、泪液炎症因子、不良反应情况。结果:联合组临床总有效率(92.00%)高于对照组(76.00%),差异有统计学意义(P<0.05)。治疗后,两组泪膜破裂时间(BUT)、基础泪腺分泌试验(SIt)、最佳矫正视力均明显升高(P<0.05),角膜荧光素染色(FL)评分、OSDI评分均明显降低(P<0.05),且联合组优于对照组(P<0.05);治疗后,两组视物不清、疼痛、流泪、畏光、睫状充血症状评分均有明显改善,且联合组优于对照组(P<0.05);治疗后,两组患者客观散射指数(OSI)明显降低,斯特列尔比(SR)明显升高(P<0.05),且联合组OSI、SR改善效果优于对照组(P<0.05);治疗后,两组超敏C反应蛋白(hs-CRP)、肿瘤坏死因子-α(TNF-α)、白细胞介素-6(IL-6)均有明显改善,且联合组炎症因子改善情况优于对照组(P<0.05)。治疗过程中两组未出现严重不良反应情况。结论:除风益损汤联合聚乙二醇滴眼液可缓解白内障术后干眼症患者临床症状,抑制炎症反应,提高泪膜稳定性,有利于促进患者术后视力恢复,提高疾病治疗效果。

Objective To analyze the therapeutic effect of Chufeng Yisun decoction combined with polyethylene glycol eye drops on dry eye syndrome after cataract surgery.Methods From August 2020to September 2022,100patients with dry eye syndrome after cataract surgery in our hospital were regarded as the research objects.They were separated into the control group(50cases,treated with polyethylene glycol eye drops)and the combined group(50cases,treated with Chufeng Yisun decoction based on control group)according to the simple random number table.Clinical efficacy,tear film stability indicators,ocular surface disease index(OSDI),optimal corrected visual acuity,tear inflammatory factors,and adverse reactions were observed and compared.Results The total clinical effective rate of the combination group(92.00%)was higher than that of the control group(76.00%)(P<0.05).After treatment,the tear film rupture time(BUT),basal lacrimal gland secretion test(SIt),and best corrected visual acuity in both groups were obviously higher(P<0.05),while the corneal fluorescence staining score(FL)and OSDI score were obviously reduced(P<0.05),and the combined group were superior to the control group(P<0.05);after treatment,both groups showed obvious improvement in symptoms such as blurred vision,pain,tearing,photophobia,and ciliary congestion,and the combined group were superior to the control group(P<0.05);after treatment,the objective scattering index(OSI)of the two groups was significantly decreased,and the streier ratio(SR)was significantly increased(P<0.05),and the improvement effect of OSI and SR in the combined group was better than that in the control group(P<0.05);after treatment,the levels of high-sensitivity C-reactive protein(hs-CRP),tumor necrosis factor-α(TNF-α)and interleukin-6(IL-6)in both groups were obviously improved,and the improvements of inflammatory factors in the combined group were better than those in the control group(P<0.05).During the treatment process,there were no serious adverse reactions in both groups.Conclusion Chufeng Yisun decoction combined with polyethylene glycol eye drops can alleviate the clinical symptoms of patients with dry eye syndrome after cataract surgery,inhibit inflammatory reaction,improve the stability of tear film,promote postoperative vision recovery,and improve the treatment effect of diseases.