补阳还五汤治疗特发性肺纤维化的临床疗效分析

Clinical Effect of Buyang Huanwu Decoction in the Treatment of Idiopathic Pulmonary Fibrosis

目的:探讨补阳还五汤对特发性肺纤维化(IPF)患者的临床疗效。方法:选取2020年6月—2022年6月于荆门市人民医院感染性疾病科就诊的IPF患者120例,随机分为对照组和治疗组各60例,对照组给予醋酸泼尼松片口服,治疗组在常规治疗的基础上给予补阳还五汤口服,治疗6个月后,比较两组患者的血清转化生长因子-β1(TGF-β1)、肿瘤坏死因子-α(TNF-α)、白细胞介素-6(IL-6)、肺活量(VC)、肺一氧化碳弥散量(DLCO)和肺总量(TLC),评估临床疗效。结果:治疗组患者TGF-β1(1.03±0.24 pg/mL vs 2.86±0.61 pg/mL)、TNF-α(5.63±1.62 pg/mL vs 9.38±1.55 pg/mL)、IL-6(58.56±3.39 pg/mL vs 64.87±3.19 pg/mL)水平均显著低于对照组(均P<0.001)。治疗6个月后,治疗组患者VC(3.89±0.69 L vs 3.14±0.71 L)、DLCO(61.93±6.59 L vs 55.64±8.30 L)及TLC[4.42(4.27,4.53)L vs 3.84(3.65,3.91)L]均显著高于对照组(均P<0.001)。治疗组患者的临床疗效明显优于对照组(P<0.05)。结论:补阳还五汤治疗IPF,可降低血清TGF-β1、TNF-α、IL-6水平,改善肺功能,临床疗效确切,值得进一步推广应用。

Objective:To explore the clinical effect of Buyang Huanwu decoction on patients with idiopathic pulmonary fibrosis(IPF).Methods:A total of 120 patients with IPF who were admitted to the Infectious Diseases Department of Jingmen People's Hospital from June 2020 to June 2022 were randomly divided into control group and treatment group,with 60 cases in each group.The control group was given prednisone acetate tablets orally,while the treatment group was given Buyang Huanwu decoction orally on the basis of routine treatment.After 6 months of treatment,the levels of serum transforming growth factor-β1(TGF-β1),tumor necrosis factor-α(TNF-α),interleukin-6(IL-6),vital capacity(VC),diffusing capacity of the lungs for carbon monoxide(DLCO)and total lung capacity(TLC)were compared between the two groups.The clinical effect was also evaluated.Results:The levels of TGF-β1(1.03±0.24 pg/mL vs 2.86±0.61 pg/mL),TNF-α(5.63±1.62 pg/mL vs 9.38±1.55 pg/mL),and IL-6(58.56±3.39 pg/mL vs 64.87±3.19 pg/mL)in the treatment group were significantly lower than those in the control group(all P<0.001).After 6 months of treatment,the VC(3.89±0.69 L vs 3.14±0.71 L),DLCO(61.93±6.59 L vs 55.64±8.30 L),and TLC[4.42(4.27,4.53)L vs 3.84(3.65,3.91)L]in the treatment group were significantly higher than those in the control group(all P<0.001).The clinical efficacy of patients in the treatment group was better than that of the control group(P<0.05).Conclusion:Buyang Huanwu decoction can reduce the levels of serum TGF-β1,TNF-α,and IL-6,and improve lung function,with a definite clinical effect on the treatment of IPF,which is worthy of further application.