发热患儿合并热性惊厥的影响因素分析

Influence Factors of Febrile Children complicated with Febrile Convulsion

目的:分析发热患儿合并热性惊厥(FC)的独立影响因素。方法:选择新疆维吾尔自治区阿合奇县人民医院2023年1月—2023年6月门诊收治的40例FC患儿作为观察组,同期门诊80例发热但未出现惊厥的患儿作为对照组。收集两组患儿的临床资料,进行单因素及多因素Logistic回归分析发热患儿合并热性惊厥的独立影响因素。结果:单因素分析结果显示,两组患儿围产期缺氧、FC家族史、缺铁性贫血、血钙、血锌、25(OH)D水平有统计学差异(均P<0.05);多因素Logistic回归分析结果显示,围产期异常(OR:24.095,95%CI:11.329,51.244)、有FC家族史(OR:5.073,95%CI:2.276,11.309)及合并缺铁性贫血(OR:6.271,95%CI:3.601,10.921)是发热患儿合并FC的独立危险因素,高血钙(OR:0.470,95%CI:0.311,0.708)、高血锌(OR:0.466,95%CI:0.379,0.575)、高25(OH)D(OR:0.653,95%CI:0.495,0.864)是发热患儿合并FC的独立保护因素。结论:患儿围产期缺氧、有FC家族史及缺铁性贫血是发热患儿合并FC的独立危险因素,高血钙、高25(OH)D及高血锌则是独立保护因素。

Objective:To analyze the independent influencing factors of febrile children complicated with febrile convulsion(FC).Methods:A total of 40 children with FC treated in the outpatient department of Aheqi County People's Hospital of Xinjiang Uygur Autonomous Region from January 2023 to June 2023 were selected as the observation group,and 80 children with fever but no convulsion were selected as the control group.The clinical data of the two groups were collected,and the independent influencing factors of febrile children complicated with febrile convulsion were analyzed by univariate and multivariate Logistic regression.Results:Univariate analysis showed that perinatal hypoxia,family history of FC,iron deficiency anemia,blood calcium,blood zinc,25(OH)D levels were statistically different between the two groups(all P<0.05).Multivariate Logistic regression analysis showed that perinatal abnormalities(OR:24.095,95%CI:11.329,51.244),family history of FC(OR:5.073,95%CI:2.276,11.309)and combined iron deficiency anemia(OR:6.271,95%CI:3.601,10.921)were independent risk factors for FC in children with fever.High blood calcium(OR:0.470,95%CI:0.311,0.708)and high blood zinc(OR:0.466,95%CI:0.379,0.575)and high 25(OH)D(OR:0.653,95%CI:0.495,0.864)were independent protective factors for FC in children with fever.Conclusion:Perinatal hypoxia,family history of FC and iron deficiency anemia are independent risk factors for FC in children with fever,while high blood calcium,high 25(OH)D and high blood zinc are independent protective factors.