谷氨酰胺与肠道损伤的关系及相关机制的研究进展

Research progress in the relationship between glutamine and intestinal injury and related mechanisms

谷氨酰胺(Gln)是人体内最丰富的游离氨基酸,是肠道细胞利用的主要底物。其通过多种信号通路发挥对肠道损伤的修复作用,主要体现在维持肠道结构的完整性,增强肠道屏障的功能,改善肠道的微生态,及促进营养物质的吸收。因此,其在肠道损伤的临床应用中也逐渐普及。本文将概括总结谷氨酰胺的生物学作用、与肠道损伤的关系、作用机制和临床应用等方面的研究进展,旨在探讨谷氨酰胺在肠道疾病领域的研究现状和发展前景。

Glutamine(Gln)is the most abundant free amino acids in the body,is the main substrate of intestinal cells.It exerts its repairing effect on intestinal injury through multiple signaling pathways,mainly reflected in maintaining the integrity of intestinal structure,enhancing the function of the intestinal barrier,improving the intestinal ecology,and promoting the absorption of nutrients.Therefore,it is also gradually popularized in the clinical application of intestinal injury.This summarize will summarize the latest research progress on the biological role of Gln,its relationship with intestinal injury,mechanism of action and clinical application.The main purpose of this summarize is intended to explore the research status and development prospects of Gln in the field of intestinal diseases.