抗菌肽的设计与临床研究策略

Design and Clinical Research Strategies of Antimicrobial Peptides

抗生素耐药性问题严重威胁着人类健康,是全球公共卫生安全的主要威胁之一。具有广谱抗菌活性、多样杀菌机制的抗菌肽作为近年来的研究热点,被认为是极具潜力的抗生素替代品。目前已有部分抗菌肽正在进行用于预防和治疗细菌病原体感染的临床试验,然而,较低的生物利用度及溶血活性等可能存在的毒副作用给天然抗菌肽的临床转化带来了障碍。因此,通过介绍抗菌肽在临床上的研究进展,并总结抗菌肽药物开发过程中的挑战及开发策略,以期为抗菌肽的药物开发提供新的思路。

Antimicrobial resistance is a serious threat to human health and global public health security.Antimicrobial peptides,which have garnered significant attention recently due to their broad-spectrum antibacterial activity and varied bactericidal processes,are being regarded as viable substitutes for antibiotics.At present,some antimicrobial peptides are undergoing clinical trials for the prevention and treatment of bacterial pathogen infections.Nevertheless,low bioavailability and significant hemolytic activity,two potentially harmful side effects,prevented antimicrobial peptides from being clinically converted.In order to provide new ideas for the drug development of antimicrobial peptides,this article introduces the research progress of antimicrobial peptides in clinical,summarizes the challenges during the drug development and provides some strategies for its development.