伏立康唑致氯气中毒患者肝损伤1例

A Case Report of Hepatic Injury in a Patient with Chlorine Poisoning Caused by Voriconazole

目的分析伏立康唑引起药物性肝损伤的原因、机制及影响因素,为临床药物性肝损伤的诊断与治疗提供参考。方法临床药师充分应用药学专业知识,参与1例氯气中毒后继发真菌感染患者的治疗过程。结果临床药师结合用药史及药物作用特点,协助医师查找和判断急性肝损伤的原因、发病机制及治疗方案,最终患者预后良好。结论临床药师参与诊疗,对患者进行用药监护,可降低不良反应的危害,提高临床用药的安全性。

Objective To analyze the causes,mechanisms and influencing factors of drug-induced liver injury caused by voriconazole,and to provide a reference for the diagnosis and treatment of drug-induced liver injury.Methods Following chlorine gas poisoning,a patient developed a secondary fungal infection.Clinical pharmacists assisted in the patient's care.ResultsBy combining the patient's medical history with the properties of the prescription,clinical pharmacists helped physicians diagnose,evaluate,and treat acute liver injury.Conclusion Clinical pharmacists participating in diagnosis,treatment and drug monitoring can reduce the harm of adverse reactions and improve the safety of clinical drugs.