辐射和儿童及青少年甲状腺癌的关系研究进展

Research progress on the relationship between radiation and thyroid cancer in children and adolescents

儿童及青少年甲状腺癌是一种少见的恶性肿瘤,病因学、临床病理特征及预后与成人甲状腺癌不同,发病率逐年上升。儿童及青少年相较成人对辐射更加敏感,辐射是导致儿童及青少年甲状腺癌较为肯定的危险因素之一。辐射的主要来源包括核事故和医疗辐射。本文对于辐射和儿童及青少年甲状腺癌发病的关系进行综述,以期提高重视辐射对于儿童及青少年甲状腺健康的危害。

Pediatric and adolescent thyroid cancer is a rare malignant tumor with etiology,clinical-pathological features,and prognosis dif-fering from adult thyroid cancer,exhibiting an increasing incidence over the years.Compared to adults,children and adolescents are more sensitive to radiation,making it a definite risk factor for the development of thyroid cancer in this population.Radiation primarily originates from nuclear accidents and medical exposure.This review comprehensively explores the molecular changes induced by radiation leading to thyroid cancer in children and adolescents,aiming to raise awareness of the hazards posed by radiation to the thyroid health of this specific age group.The in-depth analysis provided in this medical review serves as a valuable reference for gaining insights into the disease mechan-ism and guiding future research endeavors.