去氢木香内酯抗肿瘤作用机制研究进展

Progress on Antitumor Mechanism of Dehydrocostus Lactone

去氢木香内酯是从菊科云木香属植物木香Aucklandia lappa Decne.的根部提取的一种倍半萜内酯类化合物,是木香的主要活性成分之一,有抗菌、消炎、抗病毒、抗溃疡、抗糖尿病和抗肿瘤等药理活性。近年,去氢木香内酯在抗肿瘤领域引起了广泛关注。研究发现,去氢木香内酯能抑制肿瘤细胞的增殖和迁移能力,对肺癌、宫颈癌等癌症有抑制作用。其抗肿瘤机制主要包括抑制肿瘤细胞增殖、抑制肿瘤细胞侵袭和迁移、诱导肿瘤细胞凋亡和逆转肿瘤细胞多药耐药。本文对近年来去氢木香内酯的抗肿瘤作用机制进行了详细综述,旨在为该类药物在临床肿瘤治疗中提供新的理论支持、新的思路以及参考。

Dehydrocostus lactone is a sesquiterpene lactone compound extracted from the root of Aucklandia lappa Decne in Asteraceae family,and it is one of the main active components with pharmacological activities such antimicrobial,anti-inflammatory,antiviral,anti-ulcer,antidiabetic and antitumor actuities.In recent years,dehydrocostus lactone has attracted wide attention in the field of antitumor therapy.It is found that dehydrocostus lactone can inhibit the proliferation and migration ability of tumor cells,and has inhibitory effect on lung cancer,cervical cancer and other cancers.Its anti-tumor mechanism mainly includes inhibition of tumor cell proliferation,inhibition of tumor cell invasion and migration,induction of tumor cell apoptosis and reversal of tumor cell multidrug resistance.In this paper,the antitumor mechanism of dehydrocostus lactone is reviewed in detail in recent years,aiming to provide new theoretical support,new ideas and references for this class of drugs in clinical tumor therapy.