摘要
胰腺癌是世界上恶劣的肿瘤之一,其存在早期诊断难于被发现,缺乏有效治疗手段以及预后效果较差等问题。近几年研究显示SLC2A5基因的上调、缺失与胰腺癌的发展、迁移相关。SLC2A5基因编码的果糖特异转运体Glut5参与细胞中果糖代谢的过程。果糖是日常生活中常见的糖源,过量摄入导致癌症的发生和迁移。该文总结了SLC2A5基因的来源、生物学功能以及其在胰腺癌中的代谢情况和作用机制,分析认为SLC2A5基因不仅影响胰腺癌生长迁移,而且可能成为胰腺癌治疗的潜在靶向研究。
Pancreatic cancer is one of the worst tumors in the world.It has questions such as difficulty in early diagnosis,lack of clinically effective treatment methods,and poor prognosis.According to the relevant literature in recent years,the up-regula-tion and deficiency of SLC2A5 gene are related to the development and migration of pancreatic cancer.The fructose-specific transporter Glut5 encoded by the SLC2A5 gene is involved in the process of fructose metabolism in cells.Fructose is a common sugar source in daily life,and excessive intake affects the occurrence and migration of cancer.This paper summarizes the source and biological function of SLC2A5 gene and the metabolism and mechanism of SLC2A5 gene in pancreatic cancer.It is consid-ered that SLC2A5 gene not only affects the growth and migration of pancreatic cancer,but also may become a potential target for the treatment of pancreatic cancer.
作者
张兰
刘森
ZHANG Lan;LIU Sen(Collaborative Innovation Center for Industrial Fermentation,Hubei University of Technology,Wuhan 430068;Key Laboratory of Fermentation Engineering,Ministry of Education,Hubei University of Technology,Wuhan 430068;Hubei Micro Sheng Yuan Biotechnology Co.,Ltd.,Ezhou 436006,China)
出处
《生物技术》
CAS
2024年第2期244-252,共9页
Biotechnology
基金
国家自然科学基金面上项目(31971150)
湖北省杰出青年基金项目(2019CFA069)
湖北省工业发酵省部共建协同创新中心开放基金。
关键词
胰腺癌
SLC2A5基因
迁移
果糖
生物学功能
代谢
机制
靶点
pancreatic cancer
SLC2A5 gene
migration
fructose
biological functions
metabolism
mechanism
target