病毒感染诱导血小板减少发病机制的研究进展

Research progress on the pathogenesis of viral infection induced thrombocytopenia

血小板减少是病毒感染性疾病的一种常见临床表现,病毒感染人体后,能够通过抑制血小板生成、增加血小板损耗、免疫损伤及促进血小板破坏等途径共同导致血小板减少。病毒感染诱导血小板减少的机制可能有骨髓抑制、巨核细胞生成缺陷,炎症诱导的凝血及血管内破坏增加导致的血小板损耗等。文章就病毒感染性疾病诱导血小板减少机制的相关研究进行综述。

Thrombocytopenia is a common clinical manifestation of viral infectious diseases.After viral infection human body,it can jointly cause thrombocytopenia by inhibiting platelet production,increasing platelet loss,immune injury and promoting platelet destruction.The mechanism of viral infection induced thrombocytopenia may include bone marrow suppression,defective megakaryocytogenesis,inflammation-induced coagulation and intravascular destruction increased resulting platelet depletion,etc.This review summarizes the mechanisms of thrombocytopenia induced by viral infectious diseases.