2023年版《国际胰腺病协会京都指南:胰腺导管内乳头状黏液性肿瘤的管理》更新要点及解读

Interpretatio1n oftheUpdated Clinica1lPractice Guidelines for Intraductal Papillary Mucinous Neoplasm of the Pancreas(2023 edition)

胰腺导管内乳头状黏液性肿瘤(IPMN)是胰腺癌的主要癌前病变之一,一旦考虑其发生癌变,则需及时手术干预。2022-07-07,第26届国际胰腺病会议在日本京都举行,期间就进一步修订IPMN诊治指南展开讨论,并制订了新版IPMN诊治指南——京都指南。该版指南系统评价5个主题的证据:高危征象和担忧特征的定义、非手术切除IPMN的随访原则、手术切除IPMN的随访原则、病理学特征及囊液分子标记物的研究。

Intraductal papillary mucinous neoplasm(IPMN)of the pancreas is one of the main precursor lesions to pancreatic cancer,and prompt surgical intervention is necessary once malignant transformation is suspected.On July 7,2022,the 26th International Symposium on Pancreatic Diseases was held in Kyoto,Japan,during which a meeting was conducted to discuss further revisions to the diagnosis and treatment guidelines for IPMN,resulting in the formulation of a new edition—Kyoto guidelines.The new edition systematically evaluates evidence collected on five main themes:revision of high-risk stigmata and worrisome features,principles of follow-up for non-surgically resected IPMN,follow-up principles for surgically resected IPMN,revisions in pathology,and research on cyst fluid molecular markers.