急性胰腺炎基础及临床转化研究进展

Advancements in both basic and clinical translational research on acute pancreatitis

急性胰腺炎(AP)起病急、并发症发生率高,是普通外科常见急症之一,如干预不及时,可向危重症转变,严重影响病人预后。目前临床上以支持治疗和手术为主要治疗方式,然而当前并无有效药物能够逆转AP发生发展。AP的发病机制包括胰蛋白酶原异常激活、病理性钙信号传导、线粒体功能障碍、自噬异常、内质网应激、炎症和免疫调节等,以此为基础,在AP病因、治疗靶点、临床转化及临床试验等方面均进行了大量的研究,为今后的临床转化提供参考。

Acute pancreatitis(AP)is one of the common emergency cases in the department of general surgery with sudden onset and a high incidence of complications.Without timely intervention,it can progress to a critical condition and significantly affect the prognosis of patients.Currently,supportive care and surgery are the main treatment methods in the clinical practice,as there are no effective drugs available to reverse the development of AP.The pathogenesis of AP includes abnormal activation of trypsinogen,pathological calcium signaling,mitochondrial dysfunction,abnormal autophagy,endoplasmic reticulum stress,inflammation,immune regulation,etc.Based on this,a large number of studies have been conducted on the etiology,therapeutic targets,clinical transformation and clinical trials of AP,providing references for future clinical transformation.