参芪地黄汤联合氯沙坦钾片治疗早期糖尿病肾病临床研究

Clinical Study on Shenqi Dihuang Decoction Combined with Losartan Potassium Tablets for Early Diabetic Kidney Disease

目的:观察参芪地黄汤联合氯沙坦钾片治疗早期糖尿病肾病(DKD)的临床疗效。方法:选取120例早期DKD患者为研究对象,按随机数字表法分为治疗组与对照组各60例。2组均给予控制血糖、控制饮食及有氧运动等基础治疗;对照组加用氯沙坦钾片口服治疗,治疗组在对照组基础上联合参芪地黄汤治疗。治疗8周后,比较2组临床疗效、血糖[空腹血糖(FBG)、餐后2 h血糖(P2hBG)及糖化血红蛋白(HbA1c)]、炎症因子[超敏C-反应蛋白(hs-CRP)、降钙素原(PCT)]及肾功能[血肌酐(SCr)、血尿素氮(BUN)、胱抑素C (CysC)]水平。结果:治疗后,治疗组总有效率为95.00%,对照组为83.33%,2组比较,差异有统计学意义(P<0.05)。治疗后,2组FBG、P2hBG、HbA1c水平均较治疗前降低(P<0.05),且治疗组FBG、P2hBG、HbA1c水平均低于对照组(P<0.05)。治疗后,2组血清hs-CRP、PCT水平均较治疗前降低(P<0.05),且治疗组血清hs-CRP、PCT水平均低于对照组(P<0.05)。治疗后,2组BUN、SCr、CysC水平均较治疗前降低(P<0.05),且治疗组上述3项指标水平均低于对照组(P<0.05)。结论:参芪地黄汤联合氯沙坦钾片治疗早期DKD有利于降低血糖水平,减轻机体炎症反应,改善肾功能,临床疗效显著。

Objective:To observe the clinical effect of Shenqi Dihuang Decoction combined with Losartan Potassium Tablets for early diabetic kidney disease(DKD).Methods:A total of 120 cases of early DKD patients were selected as study subjects and divided into the treatment group and the control group according to the random number table method,with 60 cases in each group.The two groups were given basic treatments such as controlling blood glucose,a strict diet,and aerobic exercise;the control group was treated with oral administration of Losartan Potassium Tablets,and the treatment group was additionally treated with Shenqi Dihuang Decoction on the basis of the control group.After 8 weeks of treatment,clinical effects and the levels of blood glucose[fasting blood glucose(FBG),2-hour postprandial blood glucose(P2hBG)and glycated hemoglobin(HbA1c)],inflammatory factors[hypersensitive C-reactive protein(hs-CRP),and procalcitonin(PCT)],and kidney function[creatinine(SCr),blood urea nitrogen(BUN),and cystatin C(CysC)]were compared between the two groups.Results:After treatment,the total effective rate was 95.00%in the treatment group and 83.33%in the control group,the difference being significant(P<0.05).After treatment,the levels of FBG,P2hBG,and HbA1c in the two groups were decreased when compared with those before treatment(P<0.05),and the levels of FBG,P2hBG,and HbA1c in the treatment group were lower than those in the control group(P<0.05).After treatment,the levels of hs-CRP and PCT in serum in the two groups were decreased when compared with those before treatment(P<0.05),and the levels of hs-CRP and PCT in the treatment group were lower than those in the control group(P<0.05).After treatment,the levels of BUN,SCr,and CysC in the two groups were decreased when compared with those before treatment(P<0.05),and the above three indicators in the treatment group were lower than those in the control group(P<0.05).Conclusion:Shenqi Dihuang Decoction combined with Losartan Potassium Tablets for early DKD is beneficial for reducing blood glucose levels,alleviating inflammatory reactions,and improving kidney function,with significant clinical effects.