缺氧与炎症在创面愈合中扮演的角色

Roles of hypoxia and inflammation in wound healing

创面愈合是一个复杂的生物学过程,缺氧和炎症是启动创面愈合和影响创面愈合进程的2个关键因素。缺氧诱导因子1α(HIF-1α)和核因子κB是缺氧和炎症环境下的重要调控因子,缺氧和炎症之间的相互作用本质上由HIF-1α和核因子κB信号通路所介导,二者失调导致的HIF-1α或核因子κB信号通路的异常表达均会影响创面微环境,导致创面异常愈合。该文讨论了缺氧和炎症对创面愈合的影响,强调了缺氧和炎症之间的相互协作对创面愈合的作用,以及二者失调对创面愈合质量的影响,并对目前缺氧和炎症信号通路的干预策略进行总结,同时对未来创面的治疗进行展望。

Wound healing is a complex biological process.Hypoxia and inflammation are the two key factors that initiate wound healing and affect the wound healing process.Hypoxia-inducible factor-1α(HIF-1α)and nuclear factorκB are the important regulators of hypoxia and inflammation.The interaction between hypoxia and inflammation is essentially mediated by HIF-1αand nuclear factorκB signaling pathways.The abnormal expression of HIF-1αor nuclear factorκB signaling pathway caused by the imbalance of hypoxia and inflammation will affect the wound microenvironment and lead to abnormal wound healing.This paper discussed the effects of hypoxia and inflammation on wound healing,emphasized the role of cooperation between hypoxia and inflammation on wound healing and the effect of their imbalance on the quality of wound healing,summarized the current intervention strategies of hypoxia and inflammation signaling pathways,and prospected the treatment of wound in the future.