外泌体携带的非编码RNA作为竞争性内源性RNA参与创面修复的研究进展

Research advances on the non-coding RNAs carried by exosomes as competitive endogenous RNAs involved in wound healing

近年来,外泌体携带的非编码RNA(ncRNA)已被证明在创面修复的多个阶段中起重要的调控作用。外泌体可以将ncRNA运输到不同的靶细胞或组织中,并调节靶基因以及下游分子的表达。而竞争性内源性RNA(ceRNA)假说的提出则提示RNA可通过竞争共同的应答元件搭建更为精细和复杂的基因调控网。因此,该综述聚焦外泌体携带的长链ncRNA和环状RNA,并讨论它们分别作为ceRNA在创面修复的炎症、细胞增殖与组织重塑等阶段中所起的调控作用,同时归纳了外泌体携带的ncRNA作为无细胞疗法的可行性,以期为创面的临床治疗提供理论基础。

In recent years,non-coding RNAs(ncRNAs)carried by exosomes have been shown to play an important regulatory role in multiple stages of wound healing.Exosomes can transport ncRNAs to different target cells or tissue and regulate the expression of target genes and downstream molecules.The proposed competing endogenous RNA(ceRNA)hypothesis suggests that RNAs can build a more sophisticated and complex gene regulatory network by competing for common response elements.Therefore,this review focuses on the long ncRNAs and circular RNAs carried by exosomes,discusses their regulatory roles as ceRNAs in the stages of inflammation,cell proliferation,and tissue remodeling in wound repair,respectively,and summarizes the feasibility of ncRNAs carried by exosomes as cell-free therapy,in order to provide a theoretical basis for clinical treatment of wounds.