多发性硬化患者维生素D水平与认知功能及残疾程度的关系

The Relationship Between Vitamin D Levels,Cognitive Function,and Degree of Disability in Patients with Multiple Sclerosis

目的研究血清25-羟维生素D水平与多发性硬化(MS)认知功能和残疾程度之间的关系。方法收集2021年10月至2023年10月就诊于内蒙古自治区人民医院的MS患者40例为观察组,另纳入性别和年龄相匹配的健康志愿者40例为健康对照组,进行血清25-羟维生素D水平检测,同时应用蒙特利尔认知评估量表(MoCA)和符号数字转换测试(SDMT)评估患者认知功能,应用扩展功能残疾状况评分量表(EDSS)评价患者残疾情况,分析血清25-羟维生素D水平与二者的关系。结果观察组血清25-羟维生素D水平为(15.28±5.60)ng/mL,低于健康对照组的(23.58±3.28)ng/mL。MS患者的25-羟维生素D水平和SDMT评分呈显著正相关关系,与MoCA评分呈显著正相关关系,而与EDSS评分呈显著负相关关系。结论MS患者维生素D缺乏可能是导致其认知功能障碍的影响因素之一,而MS患者功能残疾进展也可能和维生素D缺乏相关。

Objective To study the relationship between serum 25-hydroxyvitamin D levels and cognitive function and disability in multiple sclerosis(MS).Methods 40 MS patients who were admitted to the People's Hospital of Inner Mongolia Autonomous Region from October 2021 to October 2023 were collected as the observation group,and 40 healthy volunteers matched for gender and age were included as the healthy control group.Serum 25-hydroxyvitamin was tested.D level detection,while using the Montreal Cognitive Assessment Scale(MoCA)and the Symbol-Digital Transition Test(SDMT)to evaluate the patient's cognitive function,using the Extended Functional Disability Status Scale(EDSS)to evaluate the patient's disability,and analyzing serum 25-hydroxy The relationship between vitamin D levels and the two.Results The serum 25-hydroxyvitamin D level of the observation group was(15.28±5.60)ng/mL,which was lower than that of the healthy control group(23.58±3.28)ng/mL.The 25-hydroxyvitamin D level in MS patients showed a significant positive correlation with the SDMT score,a significant positive correlation with the MoCA score,and a significant negative correlation with the EDSS score.Conclusion Vitamin D deficiency in MS patients may be one of the influencing factors leading to cognitive dysfunction,and the progression of functional disability in MS patients may also be related to vitamin D deficiency.