中药内服治疗高尿酸血症疗效的Meta分析

Meta-analysis of the Efficacy of TCM Medicine Medicine for Hyperuricemia

目的系统评价中药内服治疗高尿酸血症(HUA)的疗效。方法通过检索万方数据库(Wan-Fang Data)、中国知网(CNKI)、维普数据库、PubMed及Cochrane图书馆等相关数据库,搜索内服中药治疗高尿酸血症的随机对照试验(RCT),检索时间为2013年1月至2023年1月,采用Revman5.4进行分析。结果共纳入符合标准的8篇文献,共642例患者,Meta分析结果显示,口服中药治疗高尿酸血症的血尿酸浓度(I_(2)=0%<50%,P=0.45)和降尿酸疗效[RR=1.13,95%CI(1.03,1.24),P=0.009]、中西医结合治疗HUA的血尿酸值(I_(2)=52%>50%,P=0.1)和降尿酸疗效(I_(2)=0%<50%,P=0.91),均优于单纯西药治疗。另外,中药治疗联合西药治疗HUA的肌酐值(I_(2)=42%<50%,P=0.16)、甘油三酯[MD=-0.43,95%CI(-0.62,-0.24),P<0.00001]与总胆固醇[MD=-0.47,95%CI(-0.60,-0.34),P<0.00001]差异具有统计学意义,其疗效均优于单纯西药治疗。结论口服中药联合西药治疗高尿酸血症疗效优于单纯西药治疗。

Objective To systematically evaluate the efficacy of oral traditional Chinese medicine(TCM)in treating hyperuricemia(HUA).Methods Relevant randomized controlled trials(RCTs)on oral TCM treatment for HUA were searched in Wan-Fang Data,CNKI,VIP Data,PubMed,and Cochrane Library from January 2013 to January 2023.A total of 8 studies involving 642 patients were included,and Revman 5.4 was used for meta-analysis.Results The meta-analysis results showed that oral traditional Chinese medicine treatment for hyperuricemia had better results compared to western medicine alone in terms of blood uric acid concentration(I_(2)=0%<50%,P=0.45)and uric acid-lowering efficacy[RR=1.13,95%CI(1.03,1.24),P=0.009].Combination therapy of traditional Chinese and Western medicine for hyperuricemia had better blood uric acid values(I_(2)=52%>50%,P=0.1)and uric acid-lowering efficacy(I_(2)=0%<50%,P=0.91)compared to Western medicine treatment alone.In addition,the combination of traditional Chinese medicine and Western medicine treatment for hyperuricemia had statistically significant differences in creatinine values(I_(2)=42%<50%,P=0.16),triglycerides[MD=-0.43,95%CI(-0.62,-0.24),P<0.00001],and total cholesterol[MD=-0.47,95%CI(-0.60,-0.34),P<0.00001],with its efficacy being better than that of Western medicine treatment alone.Conclusion Oral TCM treatment is more effective than Western medicine alone in reducing serum uric acid levels in patients with HUA.