红细胞分布宽度与淋巴细胞比值、血小板与淋巴细胞比值联合癌胚抗原对结直肠癌的诊断价值

Diagnostic Value of Red Blood Cell Distribution Width to Lymphocyte Ratio,Platelet to Lymphocyte Ratio Combined with Carcinoembryonic Antigen in Colorectal Cancer

目的探讨应用外周血红细胞分布宽度与淋巴细胞比值(RLR),以及血小板与淋巴细胞比值(PLR)联合癌胚抗原(CEA)对诊断结直肠癌的价值。方法选取2020年2月-2023年2月于安徽医科大学附属巢湖医院初次诊断结直肠癌患者116例为研究组,另选取同期的住院结直肠腺瘤性息肉患者121例为息肉组,体检中心137名健康体检者为对照组,比较三组外周血红细胞分布宽度、淋巴细胞计数、血小板计数、RLR、PLR、CEA水平。通过受试者工作特征曲线(ROC)测定并判断RLR、PLR、CEA单独及联合诊断结直肠癌的诊断价值。结果研究组红细胞分布宽度、CEA水平高于息肉组和对照组,RLR、PLR水平高于对照组,淋巴细胞计数低于对照组,差异有统计学意义(P<0.017);息肉组RLR、PLR及CEA水平高于对照组,淋巴细胞计数低于对照组,差异有统计学意义(P<0.017);通过ROC曲线分析显示,RLR、PLR联合CEA对结直肠癌诊断的敏感性为66.67%,特异性为71.53%,AUC为0.755(95%CI:0.706~0.803),较指标单独及两两联合检测具有更高的诊断价值(P<0.05)。结论应用RLR、PLR、CEA对诊断结直肠癌有较高的诊断效能,RLR、PLR、CEA联合应用可提高其诊断价值。

Objective To investigate the value of red blood cell distribution width to lymphocyte ratio(RLR)and platelet to lymphocyte ratio(PLR)combined with carcinoembryonic antigen(CEA)in the diagnosis of colorectal cancer.Methods From February 2020 to February 2023,116 patients with colorectal cancer diagnosed for the first time in Chaohu Hospital of Anhui Medical University were selected as the study group,121 patients with colorectal adenomatous polyps were selected as the polyp group,and 137 healthy subjects in the physical examination center were selected as the control group.The peripheral blood red blood cell distribution width,lymphocyte count,platelet count,RLR,PLR and CEA levels were compared among the three groups.The diagnostic value of RLR,PLR and CEA alone and in combination in the diagnosis of colorectal cancer was determined by receiver operating characteristic curve(ROC).Results The red blood cell distribution width and CEA level in the study group were higher than those in the polyp group and the control group,the RLR and PLR levels were higher than those in the control group,and the lymphocyte count was lower than that in the control group,the differences were statistically significant(P<0.017);the levels of RLR,PLR and CEA in the polyp group were higher than those in the control group,and the lymphocyte count was lower than that in the control group(P<0.017).ROC curve analysis showed that the sensitivity of RLR,PLR combined with CEA in the diagnosis of colorectal cancer was 66.67%,the specificity was 71.53%,and the AUC was 0.755(95%CI:0.706-0.803),which was higher than that of the index alone and the combined detection(P<0.05).Conclusion The application of RLR,PLR and CEA has a high diagnostic efficiency in the diagnosis of colorectal cancer,and the combined application of RLR,PLR and CEA can improve its diagnostic value.