凝血检验指标在弥漫性血管内凝血诊断中的应用

Application of Coagulation Test Indexes in the Diagnosis of Disseminated Intravascular Coagulation

目的研究凝血检验指标在弥漫性血管内凝血(DIC)诊断中的应用价值。方法选取2019年6月-2022年11月我院收治的30例DIC患者设为DIC组,另取同期体检健康者30名设为健康组,均进行凝血检验[活化部分凝血酶原时间(APTT)、凝血酶原时间(PT)、凝血酶时间(TT)、D-二聚体(D-D)、纤维蛋白原(FIB)]。比较两组凝血指标检验结果,统计不同类型DIC患者的凝血指标检验结果,分析凝血检验指标在DIC中的诊断价值。结果DIC组APTT、PT、TT、D-D均高于健康组,FIB低于健康组(P<0.05)。DIC组检验结果中,APTT、PT、TT指标由高至低依次为继发性纤溶亢进期>消耗性低凝期>高凝期(P<0.05),D-D、FIB指标由高至低依次为高凝期>消耗性低凝期>继发性纤溶亢进期(P<0.05)。凝血指标APTT、PT、TT、D-D、FIB对DIC均具有确切诊断价值(AUC>0.5,P<0.05),且联合检验AUC值相对更高。结论凝血检验指标在DIC诊断中具有确切诊断效能。

Objective To study the application value of coagulation test indexes in the diagnosis of disseminated intravascular coagulation(DIC).Methods A total of 30 patients with DIC admitted to our hospital from June 2019 to November 2022 were selected as the DIC group,and 30 healthy people who underwent physical examination during the same period were selected as the healthy group.All patients underwent coagulation tests[activated partial thromboplastin time(APTT),prothrombin time(PT),thrombin time(TT),D-dimer(D-D),fibrinogen(FIB)].The test results of coagulation indexes were compared between the two groups.The test results of coagulation indexes in patients with different types of DIC were statistically analyzed,and the diagnostic value of coagulation test indexes in DIC was analyzed.Results APTT,PT,TT and D-D in the DIC group were higher than those in the healthy group,and FIB was lower than that in the healthy group(P<0.05).In the test results of the DIC group,the indexes of APTT,PT,and TT from high to low were secondary hyperfibrinolysis>consumptive low coagulation period>high coagulation period(P<0.05),the indexes of D-D and FIB from high to low were high coagulation period>consumptive low coagulation period>secondary hyperfibrinolysis period(P<0.05).The coagulation indexes APTT,PT,TT,D-D and FIB had definite diagnostic value for DIC(AUC>0.5,P<0.05),and the AUC value of combined test was relatively higher.Conclusion Coagulation test indexes have definite diagnostic efficacy in the diagnosis of DIC.