髓过氧化物酶相关疾病及其检测方法

Myeloperoxidase-related Diseases and its Detection Methods

髓过氧化物酶(MPO)是一种富含血红素的过氧化物酶,在过氧化氢(H_(2)O_(2))和卤化物作用下,MPO催化可形成杀菌活性氧化剂和自由基。现在MPO衍生的氯化化合物已经成为了许多疾病发展的生物标志物。因此了解MPO的致病机理有助于开发益于治疗MPO的抑制剂,以减轻MPO衍生氧化剂的负面影响。本文主要介绍MPO在生理学上的作用和性质、MPO的相关疾病及目前在体内外直接或间接检测MPO活性的方法。旨在为MPO的相关研究和疾病诊断提供更全面的信息。

Myeloperoxidase(MPO)is a heme-rich peroxidase that catalyzes the formation of bactericidal oxidants and free radicals under the action of hydrogen peroxide(H_(2)O_(2))and halides.Now MPO-derived chlorinated compounds have become biomarkers for the development of many diseases.Therefore,understanding the pathogenesis of MPO is helpful to develop inhibitors that are beneficial to the treatment of MPO,so as to reduce the negative effects of MPO-derived oxidants.This article mainly introduces the physiological role and nature of MPO,MPO-related diseases,and current methods for direct or indirect detection of MPO activity in vivo and in vitro.The aim is to provide more comprehensive information for MPO related research and disease diagnosis.