糖尿病肾病病理机制及其与葡萄糖目标范围内时间的关系研究

Study on the Pathological Mechanism of Diabetic Nephropathy and its Relationship with the Time in Target Glucose Range

随着糖尿病发病率的增高,糖尿病肾病(DKD)的发病率亦逐年递增。由糖尿病导致的终末期肾脏病发病率已经超过了肾小球肾炎引起的终末期肾脏病,是目前造成终末期肾病的首要原因。因此,对DKD患者进行长期综合管理与治疗尤为重要,而血糖监测是其管理的重要组成部分。《中国2型糖尿病防治指南(2020年版)》推荐葡萄糖目标范围内时间(TIR)这一指标作为糖尿病患者血糖监测管理的重要手段。对于DKD患者的血糖管理而言,TIR亦发挥重要角色。本文从TIR产生背景、DKD的诊断及病理机制、TIR与DKD关系研究方面作一综述。

With the increasing incidence of diabetes,the incidence of diabetic kidney disease(DKD)is also increasing year by year.The incidence of end-stage renal disease caused by diabetes has exceeded that caused by glomerulonephritis,which is the primary cause of end-stage renal disease.Therefore,long-term comprehensive management and treatment of patients with diabetic nephropathy is particularly important,and blood glucose monitoring is an important part of its management.The Clinical Guidelines for Prevention and Treatment of Type 2 Diabetes Mellitus in the Elderly in China(2020 edition)recommends the indicator of time in range(TIR)as an important means of blood glucose monitoring and management in diabetes mellitus patients.TIR also plays an important role in the management of blood glucose in patients with diabetic nephropathy.This article reviews the background of TIR,the diagnosis and pathological mechanism of diabetic nephropathy,and the relationship between TIR and diabetic nephropathy.