乳腺癌患者糖类抗原153和异常糖链糖蛋白水平变化及与复发的关系分析

Analysis on the changes of carbohydrate antigen 153 and tumor abnormal protein levels and the relationships with recurrence

目的 分析乳腺癌患者糖类抗原153(CA153)、异常糖链糖蛋白(TAP)水平变化及与复发的关系。方法 选取2020年10月—2022年10月嘉兴市中医医院收治的110例乳腺癌患者为乳腺癌组,另选取于嘉兴市中医医院进行体检的健康女性80例为健康组。检测两组CA153、TAP水平。乳腺癌组患者进行为期1年复查随访,统计复发情况,并分析复发的影响因素及CA153、TAP对乳腺癌复发的预测价值。结果 健康组CA153、TAP水平分别为(17.03±2.78)U/ml、(74.23±9.82)μm^(2);乳腺癌组CA153、TAP水平分别为(38.79±4.01)U/ml、(165.79±20.37)μm^(2)。与健康组相比,乳腺癌组CA153、TAP水平均较高(t=41.768,37.166,均P<0.05)。乳腺癌组治疗前后CA153、TAP水平对比,差异均有统计学意义(均P<0.05)。110例乳腺癌患者中,未复发100例,复发10例。多因素logistic回归分析结果显示:肿瘤直径、TNM分期、放疗、化疗、腋窝淋巴结转移、CA153、TAP是影响乳腺癌复发的主要因素(均P<0.05)。与CA153、TAP单项检测相比,两项联合预测乳腺癌患者复发的灵敏度、准确度均较高(均P<0.05)。结论 乳腺癌患者治疗后CA153、TAP水平下降,肿瘤直径、TNM分期、放疗、化疗、腋窝淋巴结转移、CA153、TAP均为乳腺癌复发的影响因素,CA153、TAP联合检测对乳腺癌复发的预测价值较高。

Objective To analyze the changes of carbohydrate antigen 153(CA153)and tumor abnormal protein(TAP)levels and the relationships with recurrence.Methods A total of 11o breast cancer patients treated in Jiaxing Hospital of Traditional Chinese Medicine from October 2020 to October 2022 were selected as breast cancer group,and 80 healthy women receiving physical examination in Jiaxing Hospital of Traditional Chinese Medicine were selected as healthy group.The levels of CA153 and TAP in the two groups were detected.The patients in breast cancer group were followed up for one year to calculate the recurrence rate,and the factors affecting recurrence and the predictive value of CA153 and TAP for recurrence of breast cancer were analyzed.Results The levels of CA153 and TAP in healthy group were(17.03±2.78)U/ml and(74.23±9.82)μm^(2),respectively;the levels of CA153 and TAP in breast cancer group were(38.79±4.01)U/ml and(165.79±20.37)μm°,respectively.Compared with healthy group,the levels of CA153 and TAP in breast cancer group were higher(t=41.768,37.166,P<0.05).In breast cancer group,there were statistically significant differences in the levels of CA153 and TAP between before and after treatment(P<0.05).Among 110 cases of breast cancer,100 cases did not recur,and 10 cases re curred.Multivariate logistic regression analysis showed that tumor diameter,TNM stage,radiotherapy,chemotherapy,axillary lymph node metastasis,CA153,and TAP were main influencing factors of recurrence of breast cancer(P<0.05):Compared with single detection of CA153 and TAP,the sensitivity and accuracy of combined prediction for recurrence of breast cancer patients were higher(P<0.05).Conclusion After treatment,the levels of CA153 and TAP in breast cancer patients decrease.Tumor diameter,TNM stage,radiotherapy,chemotherapy,axillary lymph node metastasis,CA153,and TAP are influencing factors of recurrence of breast cancer.The combined detection of CA153 and TAP has a high predictive value for recurrence of breast cancer.