间苯三酚联合低分子肝素对先兆流产合并绒毛膜下血肿患者人绒毛膜促性腺激素和D-二聚体水平的影响

ffects of phloroglyphol combined with low molecular weight heparin on hCG and D-D levels in threatened abortion patients with subchorionic hematoma

目的 间苯三酚联合低分子肝素对先兆流产合并绒毛膜下血肿患者人绒毛膜促性腺激素(hCG)、D-二聚体(D-D)水平的影响。方法 选取2019年8月—2021年8月杭州师范大学附属萧山医院收治的先兆流产合并绒毛膜下血肿患者106例,盲法分为对照组和观察组,分别给予单纯低分子肝素及间苯三酚联合治疗两周。对比两组患者hCG、D-D、性激素[雌二醇(E2)、孕酮(P)]、白细胞介素-10(IL-10)、干扰素-γ(IFN-γ)水平及临床疗效。结果 治疗后,与对照组SCH积(253±0.38)cm^(2)、阴道出血(11.00±1.68)d、血肿消失(15.69±3.51)d及流产征象消失(2.11±0.67)周相比,观察组患SCH面积(0.98±0.27)cm^(2)较小,阴道出血(7.26±1.32)d、血肿消失(7.44±2.00)d及流产征象消失(1.36±0.47)周均较短(P<0.05);治疗后,与对照组hCG(115 353.11±43 000.45)IU/L、E2(1 854.33±876.65)pg/ml、P(38.55±7.20)ng/ml、IL-10(2.40±0.23)pg/ml、D-D(0.39±010)μg/ml及INF-γ(6.57±0.44)pg/ml水平相比,观察组hCG(135 581.22±30 522.04)IU/L、E2(2 472.53±936.13)pg/ml、P(47.02±6.58)ng/ml、IL-10(2.97±0.30)pg/ml水平较高,D-D(0.21±0.09)μg/m及IFN-γ(3.10±0.16)pg/ml水平较低(P<0.05),观察组治疗有效(94.34%)、保胎成功率(94.34%)显著高于对照组治疗有效率(77.36%)、保胎成功率(81.13%),差异有统计学意义(P<0.05)。结论 间苯三酚联合低分子肝素可有效提升先兆流产合并绒毛膜下血肿临床疗效,调节hCG、D-D及性激素水平,抑制机体炎症扩散。

Objective Effects of phloroglactil combined with low molecular weight heparin on human Chorionic gonadotropin(hCG)and D-Dimer(D-D)levels in patients with threatened abortion complicated with subchorionic hematoma.Methods A total of 106 patients with threatened abortion complicated with subchorionic hematoma admitted to our hospital from August 2019 to August 2021 were selected.They were randomly divided into control group and observation group by blind method,and were given combined treatment of low molecular weight heparin alone and phloroglectin for 2 weeks respectively.The levels of hCG,D-D,sex hormones Estradiol(E,),progesterone(P)J,interleukin-10(IL-10),interferon-(IFN-)and clinical efficacy were compared between 2 groups.Results After treatment,compared with the control group,SCH volume(253±0.38)cm^(2),vaginal bleeding(11.00±1.68)days,hematoma disappeared(15.69±3.51)days and abortion signs disappeared(2.11±0.67)weeks,the affected SCH area(0.98±0.27)cm^(2)in the observation group was smaller.Vaginal bleeding(7.26±1.32)days,hematoma disappeared(7.44±2.00)days and signs of abortion disappeared(1.36±0.47)weeks were shorter(P<0.05).After treatment,In the control group,hCG(115353.11±43000.45)IU/L,E,(1 Compared with 854.33±876.65)pg/ml,P(38.55±7.20)ng/ml,IL-10(2.40±0.23)pg/ml,D-D(0.39±010)μg/ml and IFN-(6.57±0.44)pg/ml levels,The levels of hCG(135581.22±30522.04)IU/L,Ez(2472.53±936.13)pg/ml,P(47.01±6.58)ng/ml and IL-10(2.97±0.30)pg/ml were higher in the observation group.D-D(0.21±0.09)μg/m and IFN-(3.10±0.16)pg/ml levels were lower(P<0.05).The treatment effectiveness(94.34%)and the success rate of fetal protection(94.34%)in the observation group were significantly higher than those in the control group(77.36%)and the success rate of fetal protection(81.13%).The difference was statistically significant(P<0.05).Conclusion Mesphenol combined with low molecular molecule heparin can effectively improve the clinical efficacy of threatened abortion with subchorionic hematoma,regulate the levels of hCG,D-D and sex hormones,and inhibit the spread of inflammation in the body.