严重少弱精子症患者卵胞质内单精子注射失败后使用供精助孕对其心理健康与勃起功能的影响

Effects of using donor sperm to assist pregnancy in patients with severe oligoasthenozoospermia after failed intracytoplasmic sperm injection on their mental health and erectile function

目的探究严重少弱精子症患者卵胞质内单精子注射(ICSI)失败后使用供精助孕对其心理健康和勃起功能的影响,为该类人群针对性心理干预的实施提供参考。方法选取2020年12月至2022年12月于同济大学附属妇产科医院行助孕治疗的严重少弱精子症患者作为研究对象。其中ICSI失败后使用供精助孕的68例设为研究组,采用倾向性评分1∶1匹配ICSI失败后继续行ICSI助孕的68例设为对照组。采用一般资料调查表、焦虑自评量表(SAS)、抑郁自评量表(SDS)、中文版知觉压力量表(CPSS)和国际勃起功能指数-5(IIEF-5)进行横断面调查,比较两组血清总睾酮水平、心理健康和勃起功能状况。结果倾向性评分匹配后,两组社会人口学资料、血清总睾酮水平比较,差异无统计学意义(P>0.05);研究组焦虑、抑郁、高压力人群占比高于对照组,勃起功能障碍发生率高于对照组,差异具有统计学意义(P<0.05)。结论严重少弱精子症患者ICSI失败后使用供精助孕对其心理健康和勃起功能影响较大,医护人员应关注此类患者的心理健康和勃起功能状况,制定针对性措施帮助此类患者积极应对。

Objective To explore the effects of using donor sperm to assist pregnancy after intracytoplasmic sperm injection(ICSI)failure in patients with severe oligoasthenozoospermia on their mental health and erectile function,and providing targeted psychological intervention references for this group of people.Methods A total of 410 infertile males severe oligoasthenozoospermia who underwent assisted pregnancy treatment at the Obstetrics and Gynecology Hospital of Tongji University from December 2020 to December 2022 were selected as the research subjects.A total of 68 patients who received donor sperm for assisted pregnancy after ICSI failure were selected as the study group,while 68 patients who continued ICSI assisted pregnancy using a propensity score of 1∶1 were selected as the control group.The general information questionnaire,self-rating anxiety scale(SAS),self-rating depression scale(SDS),Chinese perceived stress scale(CPSS),and international erectile function index-5(IIEF-5)were used to conduct a cross-sectional survey.Total testosterone,mental health,and erectile function status of the two groups were compared.Results There were no significant differences in the social demography data and serum total testosterone levels between the two groups after the propensity score matching(P>0.05).The proportion of individuals with anxiety,depression,and high stress in the study group was higher than those in the control group,and the incidence of erectile dysfunction was higher than that in the control group,the difference is statistically significant(P<0.05).Conclusions The use of donor sperm to assist pregnancy in patients with severe oligoasthenozoospermia after ICSI failure has a significant impact on their mental health and erectile function.Medical staff should pay attention to the mental health and erectile function status of such patients,and develop targeted measures to help them positively respond.