精神分裂症患者代谢障碍与认知功能损害的相关研究

Correlations between Metabolic Disorders and Cognitive Impairment in Schizophrenia

目的:探讨精神分裂症患者代谢紊乱与认知功能障碍的相关性,从而明确代谢障碍能否加重认知损害。方法:招募精神分裂症患者及健康对照,以抗精神病药治疗后体重增幅≥7%将精神分裂症患者分为体重增加组与体重未增组。采用MATRICS共识认知成套测验(MCCB)评估患者的认知功能,测量身高、体重、腰围、臀围,并检测空腹血糖、甘油三酯、总胆固醇(TC)、高密度脂蛋白胆固醇(HDL-C)、低密度脂蛋白胆固醇(LDL-C)与胰岛素等糖脂代谢指标。结果:体重增加组相对于体重未增组,异常的代谢指标更多,MCCB评分更低。精神分裂症患者中,体重、体重指数(BMI)分别与信息处理速度、词语学习负相关,血脂异常与社会认知损害相关。结论:精神分裂症患者的代谢紊乱与认知损害明显相关,代谢障碍会加重患者的认知损害。

Objective:To explore the changes of metabolism and cognitive function in patients with schizophrenia after weight gain and their associations.Methods:Patients with schizophrenia and healthy controls were recruited.Patients were divided into two groups based on whether they gained weight by≥7%during antipsychotic treatment.Participants complet⁃ed MATRICS Consensus Cognitive Suite Battery(MCCB)and had their height,weight,waist and hip circumferences mea⁃sured,as well as fasting serum glucose,triglycerides,total cholesterol(TC),high-density lipoprotein cholesterol(HDL-C),low-density lipoprotein cholesterol(LDL-C),and insulin tested.Results:Compared with the non-weight gain group,the weight gain group had more abnormal metabolic parameters and worse MCCB performance.In patients with schizophrenia,body weight and body mass index(BMI)were negatively correlated with neurocognitive scores,and abnormal blood lipid profile was associated with social cognitive impairment.Conclusion:Patients with schizophrenia who gain weight have more metabolic abnormalities and worse cognitive impairment.Metabolic disorders are associated with cognitive impair⁃ment in schizophrenia.