层状双氢氧化物纳米材料在肿瘤治疗中的研究进展

Research progress of layered double hydroxide nanomaterials in treatment of cancer

层状双氢氧化物(LDHs)纳米材料是一种具有多层结构的二维纳米材料,由于特殊的结构组成,其可以作为"分子开关",在特定的生理pH条件下实现有效载荷的可控释放,但在血液循环过程中可以保持稳定。此外,LDHs本身由几种特定的阳离子组成,具有在各种细胞功能中的特定调节作用。除了优异的载药性能之外,LDHs可响应肿瘤微环境而智能释药,降低药物的不良反应,增强肿瘤杀伤作用,在肿瘤治疗领域有着广泛的应用。主要综述了LDHs用于化疗药物递送、免疫治疗、光动力治疗和免疫联合治疗肿瘤的研究进展。

Layered double hydroxides(LDHs)nanomaterial is a two-dimensional nanomaterial with a multi-layer structure.Due to their unique structural composition,LDHs can act as a"molecular switch"to achieve controllable release of payload under specific physiological pH conditions while remaining stable during blood circulation.In addition,LDHs are composed of several specific cations and have specific regulatory effects on various cellular functions.In addition to the excellent drug loading performance,LDHs can respond to the tumor microenvironment and realize a smart release of drugs,reduce the side effects of drugs,and enhance the tumor killing effect,having a wide range of applications in the field of tumor therapy.In this paper,the research progress of LDHs for chemotherapy drug delivery,immunotherapy,photodynamic therapy,and immunocombination therapy for tumors was reviewed.