^(18)F-FDG PET-CT联合血清SCC-Ag、CYFRA21-1对宫颈鳞癌腹膜后淋巴结转移的诊断价值研究

Diagnostic Value of^(18)F-FDG PET-CT Combined with Serum SCC-Ag and CYFRA21-1 in the Detection of Retroperitoneal Lymph Node Metastasis in Cervical Squamous Cell Carcinoma

目的探讨^(18)F-FDG PET-CT联合血清SCC-Ag和CYFRA21-1对宫颈鳞癌腹膜后淋巴结转移的诊断价值。方法根据术后病理学检查结果,将100例宫颈鳞癌女性患者划分为转移组(合并腹膜后淋巴结转移,33例)和非转移组(未合并腹膜后淋巴结转移,67例)。收集患者术前的^(18)F-FDG PET-CT扫描数据以及血清SCC-Ag和CYFRA21-1含量检查结果,比较两组各指标差异。通过Logistic二元多因素回归分析,分析影响宫颈鳞癌发生腹膜后淋巴结转移的独立因素,对有意义的变量进行ROC曲线分析。结果转移组血清SCC-Ag、CYFRA21-1含量以及SUVmax值均高于未转移组,组间数据差异具有统计学意义(P<0.05)。SCC-Ag、CYFRA21-1含量以及SUVmax值均被确认为宫颈鳞癌发生腹膜后淋巴结转移的独立影响因素。ROC曲线分析显示,SCC-Ag、CYFRA21-1、SUVmax单独及联合预测因子在宫颈鳞癌腹膜后淋巴结转移中的AUC分别为0.769、0.813、0.811、0.891,均具有统计学意义(P<0.05)。结论^(18)F-FDG PET-CT联合血清SCC-Ag和CYFRA21-1在宫颈鳞癌腹膜后淋巴结转移的诊断中具有显著的临床价值。

Objective To explore the diagnostic value of^(18)F-FDG PET-CT combined with serum SCC-Ag and CYFRA21-1 in detecting retroperitoneal lymph node metastasis in cervical squamous cell carcinoma.Methods Based on postoperative pathological examination results,100 female patients with cervical squamous cell carcinoma were divided into the metastasis group(33 cases with retroperitoneal lymph node metastasis)and the non-metastasis group(67 cases without retroperitoneal lymph node metastasis).Preoperative^(18)F-FDG PET-CT scan data and serum SCC-Ag and CYFRA21-1 levels were collected for each patient.Differences in various indicators between the two groups were compared.Logistic binary multivariate regression analysis was performed to identify independent factors influencing retroperitoneal lymph node metastasis.ROC curve analysis was conducted for significant variables.Results The metastasis group had significantly higher levels of serum SCC-Ag,CYFRA21-1,and SUVmax values compared to the non-metastasis group,with statistically significant differences(P<0.05).Serum SCC-Ag,CYFRA21-1 levels,and SUVmax values were identified as independent factors influencing retroperitoneal lymph node metastasis.ROC curve analysis showed that the AUCs for SCC-Ag,CYFRA21-1,SUVmax alone,and their combination in predicting retroperitoneal lymph node metastasis were 0.769,0.813,0.811,and 0.891,respectively,all of which were statistically significant(P<0.05).Conclusion The combination of^(18)F-FDG PET-CT with serum SCC-Ag and CYFRA21-1 demonstrates significant clinical value in diagnosing retroperitoneal lymph node metastasis in cervical squamous cell carcinoma.