摘要
Primary cilia,microtubule-based cellular protrusions found on the surface of nearly all eukaryotic cells,serve as crucial signaling hubs[1].These antenna-like organelles play a pivotal role in perceiving environmental stimuli,thereby orchestrating cellular behavior and fate.Primary cilia are essential for various signaling pathways,including the Sonic Hedgehog(SHH)pathway.Ciliary dysfunction can affect multiple organ systems and manifest as a spectrum of genetic disorders collectively termed as ciliopathies.However,until recently,their involvement in circadian rhythms was unknown.
