精神分裂症患者肠道菌群特征及其与炎症因子水平的关系

Characteristics of gut microbiota and its relationship with levels of inflammatory factors in patients with schizophrenia

目的分析精神分裂症(SCZ)患者肠道菌群特征,并探讨SCZ患者肠道菌群与炎症因子水平的关系。方法选择衢州市第三医院精神科2021年12月至2022年12月收治的首发SCZ患者为观察组,共68例;随机选择同期我院健康体检者为对照组,共70例。观察两组对象肠道菌群特征及血清炎症因子水平差异,并分析肠道菌群与炎症因子水平的关系。结果观察组患者肠道菌群中双歧杆菌和乳杆菌数量均低于对照组,而拟杆菌数量多于对照组(均P<0.001)。与对照组相比,观察组患者血清炎症因子水平升高(P<0.001)。Pearson相关性分析显示,双歧杆菌、乳杆菌与炎症因子水平均呈负相关(均r<0,均P<0.05),而拟杆菌与炎症因子水平呈正相关(均r>0,均P<0.05)。结论SCZ患者存在肠道菌群失衡情况,双歧杆菌和乳杆菌等有益菌数量减少,而拟杆菌等条件致病菌数量增多,并与机体炎症因子水平密切相关。

Objective To analyze the characteristics of intestinal flora in schizophrenic(SCZ)patients and the relationship between intestinal flora and inflammatory factors.Methods A total of 68 first-episode SCZ patients admitted to the Department of Psychiatry,the Third Hospital of Quzhou City from December 2021 to December 2022 were included in the observation group.A total of 70 healthy subjects were randomly selected and included in the control group.The characteristics of intestinal flora and serum levels of inflammatory factors were observed between the two groups,and the relationship between intestinal flora and levels of inflammatory factors was analyzed.Results The counts of intestinal Bifidobacterium and Lactobacillus in the observation group were lower,while that of Bacteroides was higher than those in the control group respectively(all P<0.001).The serum inflammatory factors in the observation group were higher than those in the control group(all P<0.001).Pearson correlation analysis showed that Bifidobacterium and Lactobacillus were negatively correlated with the levels of inflammatory factors(all r<0,all P<0.05),while Bacteroides was positively correlated with the levels of inflammatory factors(all r>0,all P<0.05).Conclusion SCZ patients have intestinal flora imbalance,the count of beneficial bacteria such as Bifidobacterium and Lactobacillus decreases,while that of opportunistic bacteria such as Bacteroides increases,which is closely related to the level of inflammatory factors in the body.