肠道菌群与骨关节炎危险因素相关性的研究进展

Progress in research on correlation between intestinal flora and risk factors of osteoarthritis

骨关节炎是一种慢性衰弱性关节疾病,以关节软骨退行性改变、软骨下骨重建和滑膜炎为主要特征。进一步确定骨关节炎的发病机制对于开发新的预防措施和完善相关治疗方法至关重要。随着分子细胞生物学的发展,肠道菌群在骨关节炎发病过程中扮演的主要角色引起了人们的关注。通过查阅国内外相关文献,人们发现肠道菌群与诱发骨关节炎的危险因素,如遗传、年龄、性别、饮食、代谢、中枢神经系统、运动和关节损伤等存在一定的相关性,从而导致骨关节炎具有个体差异性。为进一步明确肠道菌群与各因素间的联系,探索骨关节炎的个体化治疗方案,本文就肠道菌群与骨关节炎常见致病因素间的相关性作一综述,以期为临床完善治疗骨关节炎的策略提供新的视角与参考。

Osteoarthritis is a common chronic debilitating joint disease characterized by degenerative changes of articular cartilage,subchondral bone remodeling and synovitis.Further identification of the potential pathogenesis of osteoarthritis is crucial for the development of new preventive measures and improvement of related treatment methods.With the development of cell biomolecular engineering,the important role of intestinal flora in the pathogenesis of osteoarthritis has attracted great attention.By access to relevant literature at home and abroad,we found that intestinal flora has certain correlation with the risk factors that induced osteoarthritis,such as genetics,age,gender,diet,metabolism,central nervous system,exercise and joint injury,which leads to the incidence of osteoarthritis with individual differences.In order to further clarify the relationship between intestinal flora and various factors and to explore individualized treatment of osteoarthritis,this article reviews the correlation between intestinal flora and common pathogenic factors of osteoarthritis,in order to provide a new perspective and reference for improving the clinical treatment of osteoarthritis.