基于分子机制及生物标志物探讨肠道微生物在酒精性肝病中的作用

Role of gut microbiome in alcohol-associated liver disease based on molecular mechanisms and biomarkers

酒精性肝病包括一系列肝脏疾病,从脂肪变性到酒精相关性肝炎、肝硬化及肝细胞癌。目前,酒精性肝病的病理生理机制尚不明确。此外,肠道微生物中的细菌、真菌和病毒在酒精性肝病的发展中发挥着主要的作用,即酒精会改变肠道微生物的功能,从而导致肝脏疾病的发生。鉴于肠道微生物、酒精和肝损伤之间具有显著相关性,肠道微生物已成为酒精性肝病潜在的生物标志物和治疗靶点。本文将重点探讨肠道微生物参与酒精性肝病发病的潜在机制,并分析肠道微生物作为监测和预后的生物标志物的潜力,旨在为酒精性肝病的治疗提供一定的借鉴。

Alcohol-associated liver disease includes a range of liver diseases,from steatosis to alcohol-related hepatitis,cirrhosis and hepatocellular carcinoma.At present,the underlying mechanisms involved in the pathophysiology of alcohol-associated liver disease remain unclear.In addition,bacteria,fungi,and viruses in the gut microbiome play an important role in the development of alcohol-associated liver disease,in which alcohol alters the function of the gut microbiome,leading to liver diseases.Given the significant correlation between gut microbiome,alcohol and liver injury,gut microbiome has emerged as a potential biomarker and therapeutic target for alcohol-associated liver disease.This review focuses on exploring the potential mechanisms by which gut microbiome may be involved in the pathogenesis of alcohol-associated liver disease,and analyzes the potential of gut microbiome as a biomarker for monitoring and prognosis,so as to provide some references for the treatment of alcohol-associated liver disease.