聚多巴胺的合成及其性能应用

Synthesis and Application of Poly-dopamine

聚多巴胺是由单体多巴胺在弱碱有氧环境中自聚而成,由于其具有优异的黏着性、生物相容性、还原性等化学性能,吸引了众多学者对其在不同领域的应用进行开发。针对聚多巴胺的具体合成途径,至今还没有完全的定论,其原因是中间产物有较多的可能性;对于聚多巴胺薄膜的制备则会受到聚合时间、单体溶液的浓度、pH值、离子溶液的种类等条件影响,聚多巴胺涂层厚度会随时间及浓度的增加而增加,当pH值提升时会加快其自聚合速率,除此之外,利用特殊设备将多巴胺溶液雾化也可以提升聚多巴胺的合成速率,当溶液存在Ca2+时会加强其黏着性能,而当溶液存在Na+时则会抑制其黏着性能;对于聚多巴胺的应用,其在生物制药、医疗器械的抗菌涂层制备、金属材料的制备、其它材料的表面改性等多个领域均有所应用。本文就聚多巴胺的合成和聚多巴胺的应用两个方面进行了简单论述,主要内容包含了对多巴胺的自聚机理、影响多巴胺自聚因素、传统聚多巴胺合成法和加速聚多巴胺合成法的介绍以及聚多巴胺在不同领域的应用潜能的归纳。

Poly-dopamine is formed by the polymerization of monomer dopamine in alkaline aerobic environment,poly-dopamine has attracted many scholars to develop its applications in different fields thanks for its excellent adhesion,biocompatibility,reduction and other chemical properties.The specific synthesis pathway of polydopamine has not been fully determined,and the reason is that there are more possibilities of intermediates.The preparation of polydopamine film will be affected by the polymerization time,the concentration of the monomer solution,the pH value,the type of ionic solution and other conditions,polydopamine coating thickness will increase with the increase of time and concentration,when pH increase will speed up the polymerization rate,in addition,using special equipment to dopamine solution atomization can also increase the synthesis rate of polydopamine,when the solution Ca 2+will strengthen its adhesive performance,and when the solution exists Na+will inhibit its adhesive performance,For the application of polydopamine,it has been used in biopharmaceutical,medical device antibacterial coating preparation,metal materials preparation,surface modification of other materials and other field.The synthesis and application of poly-dopamine were discussed,the main content included the introduction of the autolerization mechanism of dopamine,the factors of affecting dopamine self-polymerization,traditional poly-dopamine synthesis method and accelerated poly-dopamine synthesis method,and the summary of the application potential of poly-dopamine in different fields.