一种pH响应型载药nMOFs的制备及其性能研究

Preparation and Performance Study on pH-responsive Drug Loaded nMOFs

以FeCl_(3)6H_(2)O和2-氨基对苯二甲酸为原料,采用水热法合成了笼型结构的纳米MOF材料MIL101-NH_(2),并将抗肿瘤药物索拉菲尼负载在材料的笼型结构中构建了载药纳米粒SRF@MIL。通过扫描电镜、X-射线粉末衍射、红外光谱、紫外光谱和热重分析,对合成的载药纳米粒进行了结构表征和性能研究。结果表明,所制备载药纳米粒粒径分布均匀,约260 nm,载药量和包封率分别为24.6%和48.3%,且有明显的pH响应性能。

A cage shaped nano MOF material MIL101-NH_(2) was synthesized by hydrothermal method using FeCl_(3)·6H_(2)O and 2-aminoterephthalic acid as raw materials,and the anti-tumor drug sorafenib was loaded into the cage structure of the material to construct drug loaded nanoparticles SRF@MIL.The structure characterization and properties of the synthesized drug loaded nanoparticles were characterized by scanning electron microscopy,X-ray powder diffraction,infrared spectroscopy,ultraviolet spectroscopy and thermogravimetric analysis.The results showed that the prepared drugdrugloaded nanoparticles had a uniform particle size distribution of about 260 nm,with drug loading and encapsulation efficiency of 24.6% and 48.3%,respectively,and significant pH responsive performance was exhibited.